(Q21989959)

English

Patched 1

mammalian protein found in Mus musculus

patched homolog 1
mesenchymal dysplasia
Ptch1
Ptch1 protein +12b
protein patched homolog 1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Transmembrane receptor, patched

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61115

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

smoothened binding

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

cholesterol binding

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

The Roslin Institute

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

protein binding

determination method

6 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

hedgehog receptor activity

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

hedgehog family protein binding

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Patched1 interacts with cyclin B1 to regulate cell cycle progression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

smoothened binding

determination method

hedgehog receptor activity

determination method

3 references

9 May 2019

A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

hedgehog family protein binding

determination method

integral component of membrane

determination method

3 references

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

plasma membrane

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

dendritic growth cone

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

axonal growth cone

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

postsynaptic density

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

plasma membrane

determination method

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Patched1 interacts with cyclin B1 to regulate cell cycle progression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

The hedgehog receptor patched is involved in cholesterol transport

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

biological process

renal system development

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

response to estradiol

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

negative regulation of smoothened signaling pathway

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

14 February 2019

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

14 February 2019

The hedgehog receptor patched is involved in cholesterol transport

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

response to organic cyclic compound

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

response to retinoic acid

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

response to mechanical stimulus

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

somite development

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

cellular response to cholesterol

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

The hedgehog receptor patched is involved in cholesterol transport

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

regulation of protein localization

determination method

regulation of smoothened signaling pathway

determination method

3 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

14 February 2019

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

embryonic limb morphogenesis

determination method

3 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

smoothened signaling pathway

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

negative regulation of cell population proliferation

determination method

smoothened signaling pathway

determination method

4 references

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

14 February 2019

Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

14 February 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

prostate gland development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

liver regeneration

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

smoothened signaling pathway

determination method

7 references

9 May 2019

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115

determination method

Sterol-sensing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61115

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000021921

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000021921

ENSMUSP00000141298

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141298

ENSMUSP00000141309

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141309

ENSMUSP00000141489

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141489

ENSMUSP00000141766

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141766

ENSMUSP00000141990

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141990

ENSMUSP00000142036

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000142036

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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