(Q21990703)

http://www.ebi.ac.uk/interpro/protein/P23950

Zinc finger, CCCH-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tis11B-like protein, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

2 references

1 reference

14 February 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

4 references

14 February 2019

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

mRNA 3'-UTR AU-rich region binding

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14-3-3 protein binding

3 references

1 reference

14 February 2019

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

3 references

14 February 2019

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

ribonucleoprotein complex

IEA

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

spongiotrophoblast layer development

biological process

1 reference

14 February 2019

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

multicellular organism growth

1 reference

14 February 2019

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

embryonic organ development

1 reference

14 February 2019

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

chorio-allantoic fusion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

1 reference

14 February 2019

The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

proepicardium development

1 reference

14 February 2019

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

1 reference

14 February 2019

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

1 reference

14 February 2019

Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

neural tube development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

cell population proliferation

1 reference

14 February 2019

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

regulation of translation

1 reference

14 February 2019

The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

1 reference

14 February 2019

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

regulation of stem cell proliferation

1 reference

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

T cell differentiation in thymus

1 reference

14 February 2019

Strong induction of the Tis11B gene in myogenic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

regulation of mRNA stability

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

positive regulation of fat cell differentiation

1 reference

14 February 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

mesendoderm development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

regulation of myoblast differentiation

1 reference

14 February 2019

Strong induction of the Tis11B gene in myogenic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

cellular response to salt stress

1 reference

14 February 2019

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

protein kinase B signaling

1 reference

14 February 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

cellular response to raffinose

1 reference

14 February 2019

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

cellular response to fibroblast growth factor stimulus

1 reference

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

multicellular organism development

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

3 references

regulation of gene expression

3 references

regulation of keratinocyte proliferation

3 references

phosphatidylinositol 3-kinase signaling

3 references

cellular response to insulin stimulus

3 references

regulation of B cell differentiation

1 reference

14 February 2019

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

regulation of keratinocyte differentiation

3 references

negative regulation of erythrocyte differentiation

3 references

positive regulation of monocyte differentiation

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

3'-UTR-mediated mRNA destabilization

IEA

8 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

24 April 2018

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

24 April 2018

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

24 April 2018

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

24 April 2018

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

24 April 2018

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23950&geneProductId=UniProtKB:P23950

cellular response to cAMP

ERK1 and ERK2 cascade

3 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

cellular response to tumor necrosis factor

3 references

cellular response to epidermal growth factor stimulus

3 references

cellular response to peptide hormone stimulus

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

cellular response to glucocorticoid stimulus

3 references

cellular response to hypoxia

3 references

cellular response to transforming growth factor beta stimulus

3 references

negative regulation of mitotic cell cycle phase transition

1 reference

14 February 2019

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

regulation of keratinocyte apoptotic process

3 references

positive regulation of intracellular mRNA localization

3 references

nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

3 references

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

3 references

3'-UTR-mediated mRNA destabilization

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23950

IBA

has part(s)

Zinc finger, CCCH-type

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23950

Tis11B-like protein, N-terminal

1 reference

stated in

InterPro Release 71.0