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TGFB-induced factor homeobox 1
mammalian protein found in Mus musculus
TG interacting factor 1
TALE family homeobox
5'-TG-3'-interacting factor 1
Tgif1
homeobox protein TGIF1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P70284
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
P70284
part of
Homeobox-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P70284
Homeobox domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Homeobox KN domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P70284
encoded by
Tgif1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P70284
molecular function
DNA binding
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70284
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IEA
JUN kinase binding
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
chromatin binding
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
TGIF inhibits retinoid signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IDA
RNA polymerase II cis-regulatory region sequence-specific DNA binding
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
DNA-binding transcription repressor activity, RNA polymerase II-specific
determination method
ISO
2 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70284&geneProductId=UniProtKB:P70284
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
protein binding
determination method
IPI
1 reference
retrieved
14 February 2019
stated in
TGIF inhibits retinoid signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IPI
co-SMAD binding
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
cell component
nucleoplasm
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
nucleus
determination method
IDA
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70284
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IEA
retrieved
14 February 2019
stated in
FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IDA
biological process
regulation of transcription, DNA-templated
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IEA
positive regulation of fibroblast proliferation
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IMP
negative regulation of retinoic acid receptor signaling pathway
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
TGIF inhibits retinoid signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IMP
negative regulation of transcription by RNA polymerase II
determination method
IGI
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
retrieved
14 February 2019
stated in
TGIF inhibits retinoid signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IGI
transcription, DNA-templated
determination method
IEA
1 reference
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P70284
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70284&geneProductId=UniProtKB:P70284
determination method
IEA
nodal signaling pathway
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IGI
neural tube closure
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Intragenic deletion of Tgif causes defectsin brain development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IMP
determination of left/right symmetry
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IMP
retina development in camera-type eye
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IDA
positive regulation of neuron differentiation
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IDA
dorsal/ventral pattern formation
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Intragenic deletion of Tgif causes defectsin brain development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IMP
regulation of gastrulation
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IGI
negative regulation of cell population proliferation
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Intragenic deletion of Tgif causes defectsin brain development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
IMP
negative regulation of gene expression
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70284
determination method
ISO
has part(s)
Homeobox domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P70284
Homeobox KN domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P70284
Identifiers
RefSeq protein ID
NP_001157546
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
NP_001157547
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
NP_001157548
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
NP_001157549
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
NP_033398
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
XP_006524095
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
XP_011244665
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
XP_036016367
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
21815
UniProt protein ID
P70284
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P70284
Ensembl protein ID
ENSMUSP00000130930
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000130930
ENSMUSP00000060512
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000060512
ENSMUSP00000139438
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000139438
ENSMUSP00000125247
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000125247
ENSMUSP00000124168
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000124168
ENSMUSP00000127139
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000127139
ENSMUSP00000115375
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000115375
ENSMUSP00000113192
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000113192
ENSMUSP00000124970
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000124970
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