(Q21992727)

http://www.ebi.ac.uk/interpro/protein/Q9EQH3

Armadillo-type fold

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9EQH3

1 reference

25 May 2022

1 reference

25 May 2022

11 references

14 February 2019

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Identification of novel retromer complexes in the mouse testis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Snx3 regulates recycling of the transferrin receptor and iron assimilation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

D1 dopamine receptor binding

IPI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

integral component of membrane

cell component

1 reference

14 February 2019

Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

3 references

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQH3&geneProductId=UniProtKB:Q9EQH3

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQH3&geneProductId=UniProtKB:Q9EQH3

31 January 2018

Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQH3&geneProductId=UniProtKB:Q9EQH3

3 references

1 reference

14 February 2019

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

3 references

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

perinuclear region of cytoplasm

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

1 reference

14 February 2019

VPS35 depletion does not impair presynaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

IDA

glutamatergic synapse

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

The Retromer Supports AMPA Receptor Trafficking During LTP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

The Retromer Supports AMPA Receptor Trafficking During LTP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

positive regulation of Wnt protein secretion

EXP

biological process

1 reference

14 February 2019

The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

2 references

positive regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

vacuolar protein processing

IGI

1 reference

14 February 2019

Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

3 references

neurotransmitter receptor transport, endosome to plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

lysosome organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

positive regulation of gene expression

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

negative regulation of gene expression

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

protein destabilization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

negative regulation of protein homooligomerization

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

protein localization to organelle

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

voluntary musculoskeletal movement

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

positive regulation of locomotion involved in locomotory behavior

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

positive regulation of dopamine biosynthetic process

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

negative regulation of protein localization

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

negative regulation of lysosomal protein catabolic process

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

retrograde transport, endosome to Golgi

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

negative regulation of neuron death

IBA

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

intracellular protein transport

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

3 references

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3