(Q22004173)

English

The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary

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scholarly article

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The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary (English)

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endoplasmic reticulum

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transmembrane transport

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cystic fibrosis

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transmembrane protein

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Sec61 translocon complex binding

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Gene Ontology release 2020-05-02

Gene Ontology ID

GOA release 2020-03-11

cystic fibrosis transmembrane conductance regulator

1 reference

GOA release 2020-03-11

5

object named as

E J Sorscher

author given names

E J

author last names

Sorscher

1 reference

PubMed publication ID

6 February 2023

author name string

Z Bebök

1

author given names

Z

author last names

Bebök

1 reference

PubMed publication ID

6 February 2023

C Mazzochi

2

author given names

C

author last names

Mazzochi

1 reference

PubMed publication ID

6 February 2023

S A King

3

author given names

S A

author last names

King

1 reference

PubMed publication ID

6 February 2023

J S Hong

4

author given names

J S

author last names

Hong

1 reference

PubMed publication ID

6 February 2023

language of work or name

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publication date

6 November 1998

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Journal of Biological Chemistry

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273

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45

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29873-8

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Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

The Sec61 complex is essential for the insertion of proteins into the membrane of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Degradation of CFTR by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanism of membrane protein integration into the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Approaching the mechanism of protein transport across the ER membrane.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

A proteolytic system that compensates for loss of proteasome function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Product review. New mammalian expression vectors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Demonstration of a peptide:N-glycosidase in the endoplasmic reticulum of rat liver

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Site-specific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct by endogenous peptide: N-glycanase as a quality control system for newly synthesized proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Similar processes mediate glycopeptide export from the endoplasmic reticulum in mammalian cells and Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Discrete cross-linking products identified during membrane protein biosynthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytosolic degradation of T-cell receptor alpha chains by the proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Cotranslational ubiquitination of cystic fibrosis transmembrane conductance regulator in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Complex, two-way traffic of molecules across the membrane of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.45.29873

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1074/JBC.273.45.29873

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PubMed publication ID

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ResearchGate publication ID

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