(Q22009393)

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function (English)

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W G Kaelin

W G Jr

Kaelin

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stated in

PubMed

PubMed publication ID

22 September 2022

C E Stebbins

1

C E

Stebbins

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stated in

PubMed

PubMed publication ID

10205047

retrieved

22 September 2022

N P Pavletich

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3

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N P

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Pavletich

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PubMed

PubMed publication ID

10205047

retrieved

22 September 2022

language of work or name

English

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publication date

16 April 1999

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published in

Science

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volume

284

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5413

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page(s)

455-61

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cites work

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

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Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog

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Characterization of Elongin C Functional Domains Required for Interaction with Elongin B and Activation of Elongin A

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Inhibition of transcription elongation by the VHL tumor suppressor protein

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

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The VHL tumour-suppressor gene paradigm

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

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(Q22009393)

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

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