(Q22009426)

English

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

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Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity (English)

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apoptotic process

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Cyclin dependent kinase inhibitor 1B

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GOA release 2020-03-11

Cyclin dependent kinase inhibitor 2C

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GOA release 2020-03-11

Cyclin dependent kinase inhibitor 2D

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GOA release 2020-03-11

Cyclin dependent kinase inhibitor 1A

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GOA release 2020-03-11

cyclin dependent kinase inhibitor 2A

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GOA release 2020-03-11

negative regulation of phosphorylation

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

M Schreiber

1

author given names

Martha

author last names

Schreiber

1 reference

Dimensions Publication ID

6 February 2023

W J Muller

2

author given names

William J

author last names

Muller

1 reference

Dimensions Publication ID

6 February 2023

G Singh

3

author given names

Gurmit

author last names

Singh

1 reference

Dimensions Publication ID

6 February 2023

F L Graham

4

author given names

Frank L

author last names

Graham

1 reference

Dimensions Publication ID

6 February 2023

language of work or name

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publication date

4 March 1999

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18

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1663-76

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9

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Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 functions as a cell cycle control protein in osteosarcomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

p21--negative regulator of the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Cdk inhibitors in development and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell-cycle regulators and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

The retinoblastoma gene family: cousins with overlapping interests.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Combination gene transfer to potentiate tumor regression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the retinoblastoma protein in the pathogenesis of human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Simultaneous determination of cell surface antigens and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Cancer cell cycles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

G1 phase progression: cycling on cue

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

C-terminal truncation of the retinoblastoma gene product leads to functional inactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

p27Kip1 overexpression causes apoptotic death of mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Why are there so many CDK inhibitors?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202466

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1202466

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Springer Nature article ID

10.1038/sj.onc.1202466

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