(Q22010220)

2

W

Luo

1 reference

7 February 2023

M Geyer

3

M

Geyer

1 reference

7 February 2023

A S Alberts

4

A S

Alberts

1 reference

7 February 2023

B M Peterlin

5

B M

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

Peterlin

1 reference

7 February 2023

language of work or name

English

0 references

publication date

June 1999

0 references

published in

Molecular Cell

0 references

volume

3

0 references

page(s)

729-39

0 references

issue

6

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Human immunodeficiency virus type 1 genome activation induced by human T-cell leukemia virus type 1 Tax protein is through cooperation of NF-kappaB and Tat.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Viral manipulations of the actin cytoskeleton.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: identification of novel HIV-1-inhibiting viral protein mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Vav links antigen-receptor signaling to the actin cytoskeleton.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Rho GTPases and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Lck regulates Vav activation of members of the Rho family of GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Interaction of invasive bacteria with host signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Vav regulates peptide-specific apoptosis in thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2980005-8

7 January 2021