(Q24322710)

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling (English)

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crystal structure

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protein structure

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FYN proto-oncogene, Src family tyrosine kinase

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GOA release 2020-03-11

disordered domain specific binding

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GOA release 2020-03-11

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based on heuristic

inferred from title

object named as

S Benichou

5

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author name string

S Arold

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P Franken

2

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M P Strub

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F Hoh

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R Benarous

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C Dumas

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language of work or name

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publication date

15 October 1997

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5

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10

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1361-72

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A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

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HIV accessory proteins: leading roles for the supporting cast.

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Immunodeficiency viruses. Not enough sans Nef.

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The role of Nef in the replication cycle of the human and simian immunodeficiency viruses

1 reference

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

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Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys

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Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques

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Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

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HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1 reference

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Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

1 reference

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based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase

1 reference

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A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease.

1 reference

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inferred from DOI database lookup

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1 reference

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inferred from DOI database lookup

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

1 reference

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based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

1 reference

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based on heuristic

inferred from DOI database lookup

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

1 reference

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based on heuristic

inferred from DOI database lookup

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The HIV-1 nef gene acts as a positive viral infectivity factor

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Src family protein tyrosine kinases and cellular signal transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Transmembrane signaling by antigen receptors of B and T lymphocytes

1 reference

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based on heuristic

inferred from DOI database lookup

Multiple kinases mediate T-cell-receptor signaling

1 reference

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based on heuristic

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Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells

1 reference

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based on heuristic

inferred from DOI database lookup

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

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based on heuristic

inferred from DOI database lookup

Protein modules and signalling networks

1 reference

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based on heuristic

inferred from DOI database lookup

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

1 reference

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inferred from DOI database lookup

Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells

1 reference

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The Src family of tyrosine protein kinases in hemopoietic signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Refined solution structure and backbone dynamics of HIV-1 Nef.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Clustered localization of oligomeric Nef protein of human immunodeficiency virus type 1 on the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Oligomerization of the Nef protein from human immunodeficiency virus (HIV) type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Solution structure and peptide binding of the SH3 domain from human Fyn

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900286-4

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based on heuristic

inferred from DOI database lookup

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

1 reference

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based on heuristic

inferred from DOI database lookup

Sequence heterogeneity of Nef transcripts in HIV-1-infected subjects at different stages of disease.

1 reference

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based on heuristic

inferred from DOI database lookup

Protein-protein interaction at crystal contacts

1 reference

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CD43-specific activation of T cells induces association of CD43 to Fyn kinase

1 reference

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inferred from DOI database lookup

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

1 reference

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based on heuristic

inferred from DOI database lookup

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

1 reference

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based on heuristic

inferred from DOI database lookup

Crystal structure of the Src family tyrosine kinase Hck

1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

The CCP4 suite: programs for protein crystallography

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1 reference

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based on heuristic

inferred from DOI database lookup

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based on heuristic

inferred from DOI database lookup

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