(Q22675690)

Metallopeptidase, catalytic domain superfamily

1 reference

PGBD-like superfamily

1 reference

PGBD superfamily

1 reference

Peptidase M10A, catalytic domain, protein family

1 reference

Hemopexin-like domain, protein family

1 reference

Peptidase, metallopeptidase family

1 reference

Peptidase M10, metallopeptidase family

1 reference

Peptidoglycan binding-like, protein family

1 reference

Peptidase M10A, cysteine switch, zinc binding site, protein family

1 reference

Hemopexin, conserved site, protein family

1 reference

Hemopexin-like repeats, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

serine-type endopeptidase activity

IEA

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22894&geneProductId=UniProtKB:P22894

1 January 2018

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22894&geneProductId=UniProtKB:P22894

1 January 2018

Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22894&geneProductId=UniProtKB:P22894

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.

IDA

endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

serine-type endopeptidase activity

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

IEA

specific granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

tertiary granule lumen

1 reference

8 April 2019

3 references

8 April 2019

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

8 April 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

GOA

curator

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

collagen-containing extracellular matrix

IBA

1 reference

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

extracellular matrix disassembly

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

endodermal cell differentiation

1 reference

8 April 2019

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

8 April 2019

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

IDA

neutrophil degranulation

1 reference

8 April 2019

regulation of neuroinflammatory response

1 reference

8 April 2019

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

regulation of microglial cell activation

1 reference

8 April 2019

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

extracellular matrix organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22894

collagen catabolic process

IBA

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL440498

has part(s)

Hemopexin-like repeats

1 reference

Peptidase, metallopeptidase

1 reference

Hemopexin, conserved site

1 reference

Peptidoglycan binding-like

1 reference

Hemopexin-like domain

1 reference

Peptidase M10A, cysteine switch, zinc binding site

1 reference

Peptidase M10A, catalytic domain

1 reference

Peptidase M10, metallopeptidase

1 reference

D08.811.277.656.300.480.205.358

Identifiers

MeSH descriptor ID

D020784

subject named as

Matrix Metalloproteinase 8

0 references

MeSH tree code

0 references

D08.811.277.656.300.480.525.700.300

0 references

D08.811.277.656.675.374.205.358

0 references

D08.811.277.656.675.374.525.700.300

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference