(Q22679043)

NADP-dependent oxidoreductase domain superfamily

1 reference

stated in

NADP-dependent oxidoreductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldo/keto reductase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

aldo-keto reductase (NADP) activity

1 reference

31 October 2017

Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

electron transfer activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

glyceraldehyde oxidoreductase activity

1 reference

8 April 2019

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

alditol:NADP+ 1-oxidoreductase activity

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

31 October 2017

The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

31 October 2017

Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

alditol:NADP+ 1-oxidoreductase activity

EXP

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

alcohol dehydrogenase (NADP+) activity

EXP

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

IBA

oxidoreductase activity

IBA

retinal dehydrogenase activity

1 reference

8 April 2019

Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

allyl-alcohol dehydrogenase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

NADP-retinol dehydrogenase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

Schwann cell microvillus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

Schmidt-Lanterman incisure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

plasma membrane bounded cell projection cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

extracellular exosome

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

IBA

extracellular exosome

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

stress-activated protein kinase signaling cascade

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

cellular response to peptide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

daunorubicin metabolic process

1 reference

8 April 2019

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

doxorubicin metabolic process

IMP

1 reference

8 April 2019

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

maternal process involved in female pregnancy

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

monosaccharide metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

norepinephrine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

fructose biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

response to thyroid hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

1 reference

31 October 2017

Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

response to water deprivation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

cellular response to methylglyoxal

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

C21-steroid hormone biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

inner medullary collecting duct development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

cellular response to hydrogen peroxide

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

sorbitol biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

renal water homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

regulation of urine volume

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

renal system development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15121&geneProductId=UniProtKB:P15121

carbohydrate metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

electron transport chain

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

cellular hyperosmotic salinity response

1 reference

8 April 2019

Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

retinoid metabolic process

1 reference

8 April 2019

Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

metanephric collecting duct development

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

retinol metabolic process

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15121

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7415

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

7404

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

7418

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL266497

has part(s)

Aldo/keto reductase, conserved site

1 reference

stated in

NADP-dependent oxidoreductase domain

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stated in

Identifiers

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

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