(Q23910756)

English

Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model

journal article published in 2002

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scholarly article

2 references

19 July 2017

Europe PubMed Central

30 November 2017

Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model (English)

1 reference

Europe PubMed Central

30 November 2017

National Institute for Occupational Safety and Health

0 references

2 references

19 July 2017

29 March 2020

exposure assessment

1 reference

19 July 2017

organophosphorus pesticide

1 reference

29 March 2020

1 reference

29 March 2020

1 reference

29 March 2020

1 reference

29 March 2020

pharmacodynamics

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

Monte Carlo method

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based on heuristic

inferred from title

Charles Timchalk

1

object named as

Timchalk C

1 reference

Europe PubMed Central

30 November 2017

author name string

Kousba A

2

1 reference

Europe PubMed Central

30 November 2017

Poet TS

3

1 reference

Europe PubMed Central

30 November 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 September 2002

1 reference

Europe PubMed Central

30 November 2017

Toxicology Letters

1 reference

Europe PubMed Central

30 November 2017

135

1 reference

Europe PubMed Central

30 November 2017

51-59

1 reference

Europe PubMed Central

30 November 2017

1-2

1 reference

Europe PubMed Central

30 November 2017

performing organization

Battelle Memorial Institute

object named as

Battelle Memorial Institute, Richland, Washington

1 reference

2 February 2024

on focus list of Wikimedia project

Wikimedia–NIOSH collaboration

0 references

1 reference

25 September 2023

Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Chlorpyrifos pharmacokinetics and metabolism following intravascular and dietary administration in channel catfish

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative desulfuration of chlorpyrifos, chlorpyrifos-methyl, and leptophos by rat brain and liver.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of aliesterase in organophosphate poisoning.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene therapy to prevent organophosphate intoxication

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A study of the polymorphism and ethnic distribution differences of human serum paraoxonase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

How to determine if an additional 10x safety factor is needed for chemicals: a case study with chlorpyrifos

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of human cytochrome P-450s in risk assessment and susceptibility to environmentally based disease

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Variability in glutathione-dependent detoxication in vivo and its relevance to detoxication of chemical mixtures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Paraoxonase protects against chlorpyrifos toxicity in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum paraoxonase status: a major factor in determining resistance to organophosphates.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic polymorphisms in human drug metabolic enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Modelling and simulation of variability and uncertainty in toxicokinetics and pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Chlorpyrifos: Pharmacokinetics in human volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Age-related differences in sensitivity to organophosphorus pesticides.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic analyses of the microsomal biotransformation of the phosphorothioate insecticides chlorpyrifos and parathion12

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian toxicology of organophosphorus pesticides.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): a computational method.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Advances in understanding drug metabolism and its contribution to variability in patient response

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900233-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0378-4274(02)00233-3

1 reference

Europe PubMed Central

30 November 2017

0 references

1 reference

Europe PubMed Central

30 November 2017

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