(Q23914707)

English

Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8- dihydrodiol

journal article published in 2003

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scholarly article

1 reference

15 October 2024

Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8- dihydrodiol (English)

1 reference

12 July 2017

National Institute for Occupational Safety and Health

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1 reference

29 March 2020

author name string

J. S. Mammen

1

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G. S. Pittman

2

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Y. Li

3

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F. Abou-Zahr

4

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B. A. Bejjani

5

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D. A. Bell

6

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P. T. Strickland

7

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T. R. Sutter

8

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language of work or name

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publication date

5 June 2003

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24

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7

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1247-1255

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performing organization

Johns Hopkins University

object named as

Johns Hopkins University

1 reference

2 February 2024

on focus list of Wikimedia project

Wikimedia–NIOSH collaboration

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1 reference

25 September 2023

The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization and functional analysis of two common human cytochrome P450 1B1 variants

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

High mutagenicity and toxicity of a diol epoxide derived from benzo(a)pyrene

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytochrome P450 1B1 gene mutations in Japanese patients with primary congenital glaucoma(1).

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Polycyclic aromatic hydrocarbons in the diet.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation and characterization of the human cytochrome P450 CYP1B1 gene

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Ethnic-related differences in the frequency distribution of genetic polymorphisms in the CYP1A1 and CYP1B1 genes in Japanese and Caucasian populations

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity of 17beta-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Catalytic properties of polymorphic human cytochrome P450 1B1 variants

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple CYP1B1 mutations and incomplete penetrance in an inbred population segregating primary congenital glaucoma suggest frequent de novo events and a dominant modifier locus.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular characterisation of congenital glaucoma in a consanguineous Canadian community: a step towards preventing glaucoma related blindness

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanisms of estrogen carcinogenesis

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGG088

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1093/CARCIN/BGG088

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