(Q24276104)

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Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

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Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model (English)

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object named as

Eng Eong Ooi

8

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object named as

Kah Hin Tan

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Subhash G Vasudevan

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object named as

Subhash G. Vasudevan

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object named as

Jenny Low

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Satoru Watanabe

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object named as

Satoru Watanabe

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author name string

Abhay P.S. Rathore

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Prasad N. Paradkar

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Cynthia Sung

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John E. Connolly

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language of work or name

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publication date

December 2011

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Antiviral Research

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92

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3

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453-460

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The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis

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6-Epicastanospermine, a novel indolizidine alkaloid that inhibits alpha-glucosidase

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Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing

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Enhanced Infection of Liver Sinusoidal Endothelial Cells in a Mouse Model of Antibody-Induced Severe Dengue Disease

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N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

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Dengue: a continuing global threat

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Unfolded protein response (UPR) gene expression during antibody-dependent enhanced infection of cultured monocytes correlates with dengue disease severity

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An adenosine nucleoside inhibitor of dengue virus

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Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

1 reference

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Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance

1 reference

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Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody

1 reference

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Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity

1 reference

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High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever

1 reference

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Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement

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A Dengue Fever Viremia Model in Mice Shows Reduction in Viral Replication and Suppression of the Inflammatory Response after Treatment with Antiviral Drugs

1 reference

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Structures of immature flavivirus particles

1 reference

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Uptake and metabolism of BuCast: a glycoprotein processing inhibitor and a potential anti-HIV drug

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EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans

1 reference

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6-0-butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs

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Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA.

1 reference

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EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

1 reference

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Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

1 reference

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Alpha-glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum

1 reference

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Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo

1 reference

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The mammalian unfolded protein response

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Flavivirus genome organization, expression, and replication

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A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice

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The NS1 glycoprotein can generate dramatic antibody-enhanced dengue viral replication in normal out-bred mice resulting in lethal multi-organ disease

1 reference

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Research on dengue during World War II

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