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Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1
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title
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1
(English)
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main subject
Apoptosis and caspase activation inhibitor
1 reference
stated in
GOA release 2020-03-11
negative regulation of apoptotic process
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stated in
GOA release 2020-03-11
Apoptosis, caspase activation inhibitor
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stated in
GOA release 2020-03-11
author name string
B N Chau
series ordinal
1
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E H Cheng
series ordinal
2
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D A Kerr
series ordinal
3
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J M Hardwick
series ordinal
4
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language of work or name
English
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publication date
July 2000
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published in
Molecular Cell
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volume
6
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page(s)
31-40
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issue
1
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cites work
The Bcl-2 protein family: arbiters of cell survival
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
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inferred from DOI database lookup
Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax-independent inhibition of apoptosis by Bcl-XL.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
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inferred from DOI database lookup
Conversion of Bcl-2 to a Bax-like death effector by caspases
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of cell death by Bcl-XL through caspase interaction
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Viral interference with apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Programmed cell death in Caenorhabditis elegans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CARD domain: a new apoptotic signalling motif
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Programmed cell death in animal development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 and Bax function independently to regulate cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bc1-2 protects mice against fatal alphavirus encephalitis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of virus-induced neuronal apoptosis by Bax.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An induced proximity model for caspase-8 activation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuronal cell death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-9 and APAF-1 form an active holoenzyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspases: intracellular signaling by proteolysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between the C. elegans cell-death regulators CED-9 and CED-4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial release of caspase-2 and -9 during the apoptotic process
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular characterization of mitochondrial apoptosis-inducing factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspases: enemies within
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suicidal tendencies: apoptotic cell death by caspase family proteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autoproteolytic activation of pro-caspases by oligomerization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Injected cytochrome c induces apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1097-2765(05)00021-3
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4448014
10.1016/S1097-2765(00)00005-8
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
5106515
Fatcat ID
release_x45y5jr6g5ckrkf2ii7hibt7b4
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/x45y5jr6g5ckrkf2ii7hibt7b4
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
4448014
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4448014
5106515
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
5106515
PubMed ID
10949025
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
5106515
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