(Q24291080)

English

The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine

scientific article

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scholarly article

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The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine (English)

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CNTFR-CLCF1 complex

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

Cardiotrophin like cytokine factor 1

1 reference

GOA release 2020-03-11

Ciliary neurotrophic factor receptor

1 reference

GOA release 2020-03-11

author name string

H Plun-Favreau

1

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G Elson

2

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M Chabbert

3

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J Froger

4

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O deLapeyrière

5

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E Lelièvre

6

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C Guillet

7

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J Hermann

8

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J F Gauchat

9

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H Gascan

10

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S Chevalier

11

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language of work or name

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publication date

2 April 2001

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The EMBO Journal

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20

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7

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1692-703

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CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Computational EST database analysis identifies a novel member of the neuropoietic cytokine family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Molecular cloning and expression of an IL-6 signal transducer, gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Neuropoietic cytokines in the hematopoietic fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

The receptor for ciliary neurotrophic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Interleukin-11 signals through the formation of a hexameric receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Gp130 and the interleukin-6 family of cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Binding interactions of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

A null mutation in the human CNTF gene is not causally related to neurological diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Exhaustive matching of the entire protein sequence database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

19 March 2017

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

7 April 2017

Structural design and molecular evolution of a cytokine receptor superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

7 April 2017

New perspectives on the design of cytokines and growth factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Receptor recognition by gp130 cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Biosynthesis and posttranslational regulation of human IL-12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Limiting dilution analysis: from frequencies to cellular interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

D1 cap region involved in the receptor recognition and neural cell survival activity of human ciliary neurotrophic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Alanine substitution for Thr268 and Asp269 of soluble ciliary neurotrophic factor (CNTF) receptor alpha component defines a specific antagonist for the CNTF response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

27 September 2017

A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

30 May 2018

Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

30 May 2018

Profile analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

30 May 2018

Recombinant human CNTF receptor alpha: production, binding stoichiometry, and characterization of its activity as a diffusible factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

30 May 2018

Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

29 November 2018

Disruption of the CNTF gene results in motor neuron degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

29 November 2018

In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145510

29 November 2018

Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor is a regulator of muscular strength in aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erythropoietin receptor activation by a ligand-induced conformation change

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid purification of embryonic rat motoneurons: an in vitro model for studying MND/ALS pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reconstitution of the response to leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood transfusion plus allograft--but not blood transfusion alone--induce IL 2-producing suppressor cells in Lew-1A recipients of LEW-1W heart allograft

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

V170 area plays an essential role in the biological activity of human ciliary neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIF (AM424), a promising growth factor for the treatment of ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/11285233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/EMBOJ/20.7.1692

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