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Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor
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title
Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor
(English)
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main subject
Receptor for activated C kinase 1
1 reference
stated in
GOA release 2020-03-11
positive regulation of protein phosphorylation
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stated in
GOA release 2020-03-11
author name string
A Gallina
series ordinal
1
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F Rossi
series ordinal
2
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G Milanesi
series ordinal
3
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language of work or name
English
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publication date
25 April 2001
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number of pages
12
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based on heuristic
inferred from page(s)
published in
Virology
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volume
283
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issue
1
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page(s)
7-18
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cites work
Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The numerous effector functions of Nef.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human immunodeficiency virus type I Nef independently affects virion incorporation of major histocompatibility complex class I molecules and virus infectivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The HIV-1 nef gene acts as a positive viral infectivity factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
G protein heterodimers: new structures propel new questions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIV-1 auxiliary proteins: making connections in a dying cell.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIV: a new role for Nef in the spread of HIV.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nef--an adaptor adaptor?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulating protein kinase C signal transduction.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ancient regulatory-protein family of WD-repeat proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New twists for dynamin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An autoregulatory region in protein kinase C: the pseudoanchoring site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Nef protein of HIV-1 associates with rafts and primes T cells for activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein Kinase C-mediated Phosphorylation of HIV-I Nef in Human Cell Lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Photoinduced inactivation of protein kinase C by dequalinium identifies the RACK-1-binding domain as a recognition site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coordinated movement of RACK1 with activated betaIIPKC
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nef-mediated clathrin-coated pit formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein structural topology: Automated analysis and diagrammatic representation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1006%2FVIRO.2001.0855
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1006/VIRO.2001.0855
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PubMed ID
11312657
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ResearchGate publication ID
12021459
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