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BACE2 functions as an alternative alpha-secretase in cells
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instance of
scholarly article
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title
BACE2 functions as an alternative alpha-secretase in cells
(English)
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main subject
Beta-secretase 2
1 reference
stated in
GOA release 2020-03-11
author name string
R Yan
series ordinal
1
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J B Munzner
series ordinal
2
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M E Shuck
series ordinal
3
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M J Bienkowski
series ordinal
4
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language of work or name
English
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publication date
7 September 2001
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published in
Journal of Biological Chemistry
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volume
276
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page(s)
34019-27
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issue
36
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cites work
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid, the presenilins and Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Q22251293
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of beta-secretase-like activity using a mass spectrometry-based assay system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and cloning of amyloid precursor protein beta-secretase from human brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression analysis of BACE2 in brain and peripheral tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Maturation and pro-peptide cleavage of beta-secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Processing of beta-secretase by furin and other members of the proprotein convertase family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation regulates intracellular trafficking of beta-secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prodomain processing of Asp1 (BACE2) is autocatalytic.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evolution of Complexity in Paleozoic Ammonoid Sutures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secretases as therapeutic targets for the treatment of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M105583200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1074/JBC.M105583200
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
89013
OpenCitations bibliographic resource ID
89013
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
89013
PubMed ID
11423558
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
89013
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