(Q43839169)

27 November 2017

title

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. (English)

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27 November 2017

Saftig P

1

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27 November 2017

Peters C

2

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27 November 2017

von Figura K

3

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27 November 2017

Craessaerts K

4

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27 November 2017

Van Leuven F

5

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27 November 2017

De Strooper B

6

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27 November 2017

language of work or name

English

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publication date

1 November 1996

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Journal of Biological Chemistry

27 November 2017

published in

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27 November 2017

volume

271

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27 November 2017

issue

44

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27 November 2017

page(s)

27241-27244

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The molecular pathology of Alzheimer's disease

27 November 2017

cites work

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

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Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

21 January 2018

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The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

21 January 2018

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

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Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

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Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

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Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.

21 January 2018

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Immunolocalization of cathepsin D in normal and neoplastic human tissues

21 January 2018

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Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

21 January 2018

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Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

21 January 2018

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Processing of the Pre‐β‐amyloid Protein by Cathepsin d is Enhanced by a Familial Alzheimer's Disease Mutation

21 January 2018

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Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

21 January 2018

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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

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Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor.

21 January 2018

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Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

21 January 2018

Identifiers

DOI

10.1074/JBC.271.44.27241

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27 November 2017

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