(Q24292273)

English

Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells

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Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells (English)

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Alzheimer's disease

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amyloid beta-peptides

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lipid metabolism

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protein fragment

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intracellular receptor

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alpha-1-antichymotrypsin

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Serpin family A member 3

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GOA release 2020-03-11

regulation of lipid metabolic process

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GOA release 2020-03-11

transcription factor

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based on heuristic

inferred from title

Sabina Janciauskiene

3

object named as

Sabina Janciauskiene

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author name string

Yong-Xin Sun

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H T Wright

2

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language of work or name

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publication date

15 February 2002

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Journal of Neuroscience Research

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67

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4

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511-22

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beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease.

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

ApoE protects cortical neurones against neurotoxicity induced by the non-fibrillar C-terminal domain of the amyloid-beta peptide.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Ca(2+)-dependent binding of human serum amyloid P component to Alzheimer's beta-amyloid peptide.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol.

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

A specific structural interaction of Alzheimer's peptide A beta 1-42 with alpha 1-antichymotrypsin.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Alzheimer's peptide Abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Fibrillar Alzheimer's amyloid peptide Abeta(1-42) stimulates low density lipoprotein binding and cell association, free radical production and cell cytotoxicity in PC12 cells.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Alpha 1-antichymotrypsin

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains.

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Proteoglycans and the acute-phase response in Alzheimer's disease brain

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

NF-kappaB in neuronal plasticity and neurodegenerative disorders

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

The Rel/NF-kappa B family: friend and foe.

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Distribution pattern and functional state of alpha 1-antichymotrypsin in plaques and vascular amyloid in Alzheimer's disease. A immunohistochemical study with monoclonal antibodies against native and inactivated alpha 1-antichymotrypsin

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Increased lipoprotein oxidation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Platelet secretion of beta-amyloid is increased in hypercholesterolaemia

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

?1-Antichymotrypsin Binding to Alzheimer A? Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

In vitro complex formation between cholesterol and alpha 1-proteinase inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

Monomeric and polymeric forms of alpha-1 antichymotrypsin in sera from patients with probable late onset Alzheimer's disease

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https://api.crossref.org/works/10.1002%2FJNR.10144

21 January 2018

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10.1002/JNR.10144

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