(Q24294292)

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Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics

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Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics (English)

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Pleckstrin homology, MyTH4 and FERM domain containing H2

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GOA release 2020-03-11

Transforming growth factor beta 1 induced transcript 1

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GOA release 2020-03-11

Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

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GOA release 2020-03-11

focal segmental glomerulosclerosis

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based on heuristic

inferred from title

Christer Betsholtz

9

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4

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Annika Wernerson

13

object named as

Annika Wernerson

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Hjalmar Brismar

11

object named as

Hjalmar Brismar

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10

object named as

Mathias Uhlen

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Ljubica Perisic

1

object named as

Ljubica Perisic

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2

object named as

Mark Lal

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Timo Pikkarainen

14

object named as

Timo Pikkarainen

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Karl Tryggvason

12

object named as

Karl Tryggvason

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Jaakko Patrakka

8

object named as

Jaakko Patrakka

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3

object named as

Jenny Hulkko

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7

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Fredrik Dunér

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author name string

Björn Önfelt

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Ying Sun

6

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language of work or name

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publication date

November 2012

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Kidney International

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82

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10

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1071-83

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New insights into the role of podocytes in proteinuria

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https://api.crossref.org/works/10.1038%2FKI.2012.252

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Hereditary proteinuria syndromes and mechanisms of proteinuria

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https://api.crossref.org/works/10.1038%2FKI.2012.252

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Cell biology of the glomerular podocyte

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https://api.crossref.org/works/10.1038%2FKI.2012.252

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Podocyte cytoskeleton is connected to the integral membrane protein podocalyxin through Na+/H+-exchanger regulatory factor 2 and ezrin

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome

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https://api.crossref.org/works/10.1038%2FKI.2012.252

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based on heuristic

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Rac1 contributes to actin organization in glomerular podocytes

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Large-scale identification of genes implicated in kidney glomerulus development and function

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Membrane recognition by phospholipid-binding domains

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https://api.crossref.org/works/10.1038%2FKI.2012.252

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Organizing the cell cortex: the role of ERM proteins

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

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The PSIPRED protein structure prediction server

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

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SCORER 2.0: an algorithm for distinguishing parallel dimeric and trimeric coiled-coil sequences

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Vertebrate MAX-1 is required for vascular patterning in zebrafish

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Myosin-X: a molecular motor at the cell's fingertips

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Phospholipid-dependent regulation of the motor activity of myosin X.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Myosin-X provides a motor-based link between integrins and the cytoskeleton.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Subdomain folding of the coiled coil leucine zipper from the bZIP transcriptional activator GCN4

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of chain length on the formation and stability of synthetic alpha-helical coiled coils

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Phosphoinositides in cell architecture.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

The human glomerular podocyte is a novel target for insulin action

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https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Insulin signaling to the glomerular podocyte is critical for normal kidney function

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Merlin differentially associates with the microtubule and actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Characterization of a myosin VII MyTH/FERM domain.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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A FERM domain autoregulates Drosophila myosin 7a activity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

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Characterization of an Actin-binding Site within the Talin FERM Domain

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-5.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Hic-5 promotes endothelial cell migration to lysophosphatidic acid.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Hic-5 regulates an epithelial program mediated by PPARgamma

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Roles of PINCH-2 in regulation of glomerular cell shape change and fibronectin matrix deposition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence variants in the PLEKHH2 region are associated with diabetic nephropathy in the GoKinD study population

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

FSGS-associated alpha-actinin-4 (K256E) impairs cytoskeletal dynamics in podocytes

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

TRPC6 and FSGS: the latest TRP channelopathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Induction of TRPC6 channel in acquired forms of proteinuric kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorescence resonance energy transfer (FRET) microscopy imaging of live cell protein localizations

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

inferred from DOI database lookup

The glomerular transcriptome and a predicted protein-protein interaction network

1 reference

https://api.crossref.org/works/10.1038%2FKI.2012.252

7 January 2021

based on heuristic

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Identifiers

10.1038/KI.2012.252

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Springer Nature article ID

10.1038/ki.2012.252

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