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Siah-1 facilitates ubiquitination and degradation of synphilin-1
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scholarly article
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title
Siah-1 facilitates ubiquitination and degradation of synphilin-1
(English)
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main subject
Synuclein alpha interacting protein
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stated in
GOA release 2020-03-11
regulation of neurotransmitter secretion
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stated in
GOA release 2020-03-11
protein ubiquitination
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based on heuristic
inferred from title
author
Nobutaka Hattori
series ordinal
7
object named as
Nobutaka Hattori
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Yoshikuni Mizuno
series ordinal
8
object named as
Yoshikuni Mizuno
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Masayasu Matsumoto
series ordinal
10
object named as
Masayasu Matsumoto
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author name string
Yoshito Nagano
series ordinal
1
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Hiroshi Yamashita
series ordinal
2
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Tetsuya Takahashi
series ordinal
3
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Shosei Kishida
series ordinal
4
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Takeshi Nakamura
series ordinal
5
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Eizo Iseki
series ordinal
6
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Akira Kikuchi
series ordinal
9
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language of work or name
English
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publication date
19 December 2003
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published in
Journal of Biological Chemistry
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volume
278
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page(s)
51504-14
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issue
51
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cites work
Synphilin-1 is present in Lewy bodies in Parkinson's disease
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
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7 January 2021
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inferred from DOI database lookup
Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
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inferred from DOI database lookup
Characterization of human homologs of the Drosophila seven in absentia (sina) gene
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
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inferred from DOI database lookup
Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
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Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
1 reference
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reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
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7 January 2021
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inferred from DOI database lookup
Lack of binding observed between human alpha-synuclein and Bcl-2 protein family
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
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Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
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inferred from DOI database lookup
Inhibitory effect of MK-801 on amantadine-induced dopamine release in the rat striatum.
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
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inferred from DOI database lookup
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf functions downstream of Ras1 in the Sevenless signal transduction pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alpha-synuclein in Lewy bodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A binding motif for Siah ubiquitin ligase.
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Siah-1 binds and regulates the function of Numb
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of synaptophysin degradation by mammalian homologues of seven in absentia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of BOB.1/OBF.1 stability by SIAH
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathology and biology of the Lewy body
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuropathology of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasomal regulation of nuclear receptor corepressor-mediated repression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M306347200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1074/JBC.M306347200
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PubMed ID
14506261
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