(Q24296507)

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Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6

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Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6 (English)

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Adenylate cyclase 6

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GOA release 2020-03-11

cellular response to forskolin

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GOA release 2020-03-11

1

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Robert A. Hegele

6

object named as

Robert A Hegele

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author name string

Stan Van Uum

2

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Adam Hutchinson-Jaffe

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Qingming Ding

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J Geoffrey Pickering

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Ross D Feldman

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language of work or name

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publication date

December 2007

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Arteriosclerosis, Thrombosis, and Vascular Biology

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27

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12

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2657-63

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LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090).

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Data normalization before statistical analysis: keeping the horse before the cart

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Circulating fibrocytes: collagen-secreting cells of the peripheral blood

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Identification of a dysfunctional missense single nucleotide variant of human adenylyl cyclase VI.

1 reference

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Insulin-mediated venodilation is impaired in young, healthy carriers of the 825T allele of the G-protein beta3 subunit gene (GNB3).

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Differential expression of adenylyl cyclase subtypes in human cardiovascular system

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Venous response to nitroglycerin is enhanced in young, healthy carriers of the 825T allele of the G protein β3 subunit gene (GNB3)

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Vanadate stimulation of adenylyl cyclase: an index of tyrosine kinase vascular effects

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Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse

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Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues

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Molecular biological approaches to unravel adenylyl cyclase signaling and function

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Tyrosine kinase-mediated serine phosphorylation of adenylyl cyclase

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Adenylyl cyclases and the interaction between calcium and cAMP signalling

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Insulin action impaired by deficiency of the G-protein subunit G ialpha2

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The human histamine H2-receptor couples more efficiently to Sf9 insect cell Gs-proteins than to insect cell Gq-proteins: limitations of Sf9 cells for the analysis of receptor/Gq-protein coupling

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The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization

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G protein-coupled receptor kinase 4 gene variants in human essential hypertension

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Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms

1 reference

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Quinapril treatment enhances vascular sensitivity to insulin

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Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.

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Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation

1 reference

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An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation

1 reference

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Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo

1 reference

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Defective vasodilatory mechanisms in hypertension: a G-protein-coupled receptor perspective.

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Isoforms of mammalian adenylyl cyclase: multiplicities of signaling

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The impact of blunted beta-adrenergic responsiveness on growth regulatory pathways in hypertension

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Regulation and role of adenylyl cyclase isoforms

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Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

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Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats

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Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase

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Effects of the G protein beta 3-subunit gene C825T polymorphism: should hypotheses regarding the molecular mechanisms underlying enhanced G protein activation be revised? Focus on "A splice variant of the G protein beta 3-subunit implicated in disea

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Adenylyl cyclase increases survival in cardiomyopathy

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Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization

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Defective venous beta-adrenergic response in borderline hypertensive subjects is corrected by a low sodium diet

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