(Q24298269)

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Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner

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Europe PubMed Central

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26 January 2020

Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445305%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

endoplasmic reticulum

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phosphorylation

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Steve Charnock-Jone

2

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26 January 2020

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Graham J Burton

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26 January 2020

author name string

Hong Wa Yung

1

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26 January 2020

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21 March 2011

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26 January 2020

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26 January 2020

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26 January 2020

e17894

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26 January 2020

3

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26 January 2020

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Creative Commons Attribution 4.0 International

21 March 2011

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April 2022 Public Data File from Crossref

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GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

19 March 2017

AKT/PKB signaling: navigating downstream

1 reference

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19 March 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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19 March 2017

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

19 March 2017

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

19 March 2017

Modulation of Akt kinase activity by binding to Hsp90

1 reference

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19 March 2017

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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19 March 2017

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

19 March 2017

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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19 March 2017

Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP

1 reference

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19 March 2017

ER chaperones in mammalian development and human diseases

1 reference

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19 March 2017

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

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19 March 2017

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

19 March 2017

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

19 March 2017

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

19 March 2017

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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19 March 2017

The nuts and bolts of AGC protein kinases

1 reference

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7 April 2017

A trip to the ER: coping with stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

7 April 2017

Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

GRP78: a multifunctional receptor on the cell surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061875

27 September 2017

GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis

1 reference

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27 September 2017

GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development

1 reference

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27 September 2017

A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells

1 reference

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27 September 2017

Stress induction of GRP78/BiP and its role in cancer.

1 reference

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Role of the unfolded protein response in cell death

1 reference

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Endoplasmic reticulum stress response and neurodegeneration

1 reference

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27 September 2017

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

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27 September 2017

HSP binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines

1 reference

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27 September 2017

Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells

1 reference

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30 May 2018

Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27.

1 reference

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30 May 2018

Evolution. Chaperones as buffering agents?

1 reference

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21 January 2018

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

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29 November 2018

Peptide-binding specificity of the molecular chaperone BiP

1 reference

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21 January 2018

Identifiers

10.1371/JOURNAL.PONE.0017894

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445305%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

2011PLoSO...617894Y

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445305%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445305%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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