(Q24298929)

English

Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking

scientific article

In more languages

Statements

scholarly article

0 references

Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking (English)

0 references

Alsin Rho guanine nucleotide exchange factor ALS2

1 reference

GOA release 2020-03-11

guanyl-nucleotide exchange factor activity

1 reference

GOA release 2020-03-11

author name string

Ryota Kunita

1

0 references

Asako Otomo

2

0 references

Hikaru Mizumura

3

0 references

Kyoko Suzuki

4

0 references

Junko Showguchi-Miyata

5

0 references

Yoshiko Yanagisawa

6

0 references

Shinji Hadano

7

0 references

Joh-E Ikeda

8

0 references

language of work or name

0 references

publication date

10 September 2004

0 references

Journal of Biological Chemistry

0 references

279

0 references

37

0 references

38626-35

0 references

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Hereditary motor system diseases (chronic juvenile amyotrophic lateral sclerosis). Conditions combining a bilateral pyramidal syndrome with limb and bulbar amyotrophy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Interaction between HERC1 and M2-type pyruvate kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Protein binding and signaling properties of RIN1 suggest a unique effector function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Junctophilins: a novel family of junctional membrane complex proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Running on Ran: nuclear transport and the mitotic spindle.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Rho GTPases in cell biology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Role of Rho family GTPases in epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Signaling the pathway to regeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Rho GTPases in neuronal morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Rab proteins as membrane organizers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

The guanine nucleotide-binding switch in three dimensions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Leucine zipper-mediated homodimerization of the p21-activated kinase-interacting factor, beta Pix. Implication for a role in cytoskeletal reorganization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Oligomerization of DH domain is essential for Dbl-induced transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

21 January 2018

Infantile onset of hereditary ascending spastic paralysis with bulbar involvement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406120200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M406120200

0 references

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q24298929&oldid=1475347329"