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Y14 and hUpf3b form an NMD-activating complex
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title
Y14 and hUpf3b form an NMD-activating complex
(English)
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main subject
UPF3B regulator of nonsense mediated mRNA decay
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stated in
GOA release 2020-03-11
author
Matthias Hentze
object named as
Matthias W Hentze
series ordinal
4
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Niels H Gehring
series ordinal
1
object named as
Niels H Gehring
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Andreas E Kulozik
series ordinal
5
object named as
Andreas E Kulozik
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author name string
Gabriele Neu-Yilik
series ordinal
2
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Thomas Schell
series ordinal
3
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language of work or name
English
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publication date
April 2003
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published in
Molecular Cell
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volume
11
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issue
4
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page(s)
939-49
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cites work
Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
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inferred from DOI database lookup
Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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inferred from DOI database lookup
Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.
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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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The human intronless melanocortin 4-receptor gene is NMD insensitive
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Translation driven by an eIF4G core domain in vivo
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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Translation is required to remove Y14 from mRNAs in the cytoplasm
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Nonsense-mediated mRNA decay in health and disease
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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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A perfect message: RNA surveillance and nonsense-mediated decay
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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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inferred from DOI database lookup
mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The protein Mago provides a link between splicing and mRNA localization.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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inferred from DOI database lookup
NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonsense surveillance in lymphocytes?
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Quality control of mRNA function
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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inferred from DOI database lookup
Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
A protein-RNA interaction network facilitates the template-independent cooperative assembly on RNA polymerase of a stable antitermination complex containing the lambda N protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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inferred from DOI database lookup
RNA events. No end to nonsense
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian orthologues of a yeast regulator of nonsense transcript stability
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Binary specification of nonsense codons by splicing and cytoplasmic translation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
based on heuristic
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The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900142-4
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7 January 2021
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Identifiers
DOI
10.1016/S1097-2765(03)00142-4
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1400781
OpenCitations bibliographic resource ID
1400781
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1400781
PubMed ID
12718880
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1400781
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