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The R1441C mutation of LRRK2 disrupts GTP hydrolysis
scientific article
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instance of
scholarly article
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title
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
(English)
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main subject
biophysics
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cell biology
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Leucine rich repeat kinase 2
1 reference
stated in
GOA release 2020-03-11
protein autophosphorylation
1 reference
stated in
GOA release 2020-03-11
author
Elisa Greggio
series ordinal
2
0 references
Alexandra Beilina
series ordinal
3
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Patrick A. Lewis
object named as
Patrick A Lewis
series ordinal
1
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Mark R Cookson
series ordinal
6
object named as
Mark R Cookson
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author name string
Shushant Jain
series ordinal
4
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Acacia Baker
series ordinal
5
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language of work or name
English
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publication date
8 June 2007
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published in
Biochemical and Biophysical Research Communications
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volume
357
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issue
3
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page(s)
668-71
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cites work
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
Kinase activity of mutant LRRK2 mediates neuronal toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
A common LRRK2 mutation in idiopathic Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
19 March 2017
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
7 April 2017
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
27 September 2017
LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
27 September 2017
Roc, a Ras/GTPase domain in complex proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973
retrieved
27 September 2017
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/17442267
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Parkinson disease gene LRRK2: evolutionary and structural insights
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/17442267
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.BBRC.2007.04.006
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1364128
OpenCitations bibliographic resource ID
1364128
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1364128
PMCID
1939973
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1364128
PubMed ID
17442267
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1364128
ResearchGate publication ID
6386923
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