(Q24305459)

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER (English)

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Insulin induced gene 1

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GOA release 2020-03-11

Sterol regulatory element binding transcription factor 2

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GOA release 2020-03-11

membrane proteins

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based on heuristic

inferred from title

Ruedi Aebersold

6

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object named as

Daisuke Yabe

4

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Joseph L. Goldstein

7

object named as

Joseph L Goldstein

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author name string

Tong Yang

1

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Peter J Espenshade

2

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Michael E Wright

3

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Yi Gong

5

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Michael S Brown

8

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language of work or name

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publication date

23 August 2002

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110

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489-500

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4

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Using temperature-sensitive mutants of VSV to study membrane protein biogenesis.

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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Transport-Dependent Proteolysis of SREBP

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Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

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Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

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Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

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Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

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19 October 2022

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Identifiers

10.1016/S0092-8674(02)00872-3

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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