(Q24306176)

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Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway

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scholarly article

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Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway (English)

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1 reference

GOA release 2020-03-11

positive regulation of protein kinase B signaling

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GOA release 2020-03-11

1 reference

based on heuristic

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author name string

Heung Sun Kwon

1

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Stanislav I Tomarev

2

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language of work or name

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publication date

December 2011

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Journal of Cellular Physiology

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226

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12

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3392-402

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Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Myocilin is a modulator of Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Integrin ligands at a glance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

The number of people with glaucoma worldwide in 2010 and 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Optimedin: a novel olfactomedin-related protein that interacts with myocilin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Signaling through focal adhesion kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

19 March 2017

Proximal events in Wnt signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

7 April 2017

Focal adhesion kinase: in command and control of cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

7 April 2017

Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Adhesion signaling - crosstalk between integrins, Src and Rho.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Signal co-operation between integrins and other receptor systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Integrins in cell migration--the actin connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Functional properties of fibronectin in the trabecular meshwork

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Glaucoma-associated myocilin: a better understanding but much more to learn

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Specialized podosome- or invadopodia-like structures (PILS) for focal trabecular meshwork extracellular matrix turnover

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

The role of integrin binding sites in fibronectin matrix assembly in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Actin stress fibres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Polymerizing actin fibers position integrins primed to probe for adhesion sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Myocilin glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Expression of wild-type and truncated myocilins in trabecular meshwork cells: their subcellular localizations and cytotoxicities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Myocilin and glaucoma: facts and ideas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Aqueous humor stimulates the migration of human trabecular meshwork cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Identification of a gene that causes primary open angle glaucoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

27 September 2017

Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

30 May 2018

Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

30 May 2018

Characterization of the mouse Myoc/Tigr gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

30 May 2018

Fibronectin induces migration of bovine trabecular meshwork cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995168

30 May 2018

Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Analysis of myocilin mutations in 1703 glaucoma patients from five different populations

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

TIGR is upregulated in the chronic glial scar in response to central nervous system injury and inhibits neurite outgrowth.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Mutated mouse and human myocilins have similar properties and do not block general secretory pathway.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Role of formation of an ERK-FAK-paxillin complex in migration of human corneal epithelial cells during wound closure in vitro.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Extracellular myocilin affects activity of human trabecular meshwork cells.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Molecular and clinical evaluation of a patient hemizygous for TIGR/MYOC.

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Primary open-angle glaucoma

1 reference

https://api.crossref.org/works/10.1002%2FJCP.22701

21 January 2018

Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Migration of cultured bovine trabecular meshwork cells to aqueous humor and constituents

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of integrin receptors in the human trabecular meshwork

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence and properties of myocilin in the aqueous humor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural localization of collagen IV, fibronectin, and laminin in the trabecular meshwork of normal and glaucomatous eyes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21656515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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