(Q24307553)

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Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation

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scholarly article

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Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation (English)

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Collaborative Research Centre (CRC) 1002: "Modulatory Units in Heart Failure"

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phosphorylation

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structural molecule activity conferring elasticity

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Gene Ontology release 2020-05-02

Gene Ontology ID

GOA release 2020-03-11

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based on heuristic

inferred from title

Calcium/calmodulin dependent protein kinase II delta

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GOA release 2020-03-11

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GOA release 2020-03-11

Calcium/calmodulin-dependent protein kinase II gamma

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GOA release 2020-03-11

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GOA release 2020-03-11

Calcium/calmodulin-dependent protein kinase II, delta

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GOA release 2020-03-11

author name string

Nazha Hamdani

1

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Judith Krysiak

2

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Michael M Kreusser

3

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Stefan Neef

4

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Cristobal G Dos Remedios

5

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Lars S Maier

6

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Markus Krüger

7

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Johannes Backs

8

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Wolfgang A Linke

9

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language of work or name

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publication date

15 February 2013

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Circulation Research

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112

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4

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664-74

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Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence

1 reference

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7 January 2021

based on heuristic

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Synergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling

1 reference

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7 January 2021

based on heuristic

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Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart

1 reference

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7 January 2021

based on heuristic

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The sarcomeric cytoskeleton: who picks up the strain?

1 reference

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7 January 2021

based on heuristic

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SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

CaMKII in myocardial hypertrophy and heart failure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Passive and active tension in single cardiac myofibrils

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Calmodulin kinase II inhibition protects against structural heart disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The cAMP binding protein Epac regulates cardiac myofilament function

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

CaMKII inhibition in heart failure, beneficial, harmful, or both

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Titin isoform switch in ischemic human heart disease.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiomyocyte Stiffness in Diastolic Heart Failure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac titin: a multifunctional giant

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential cardiac remodeling in preload versus afterload

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.111.300105

7 January 2021

based on heuristic

inferred from DOI database lookup

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