(Q24308109)

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Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates

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scholarly article

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Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates (English)

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crystal structure

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5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

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GOA release 2020-03-11

protein homodimerization activity

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GOA release 2020-03-11

Ian Andrew Wilson

6

object named as

Ian A Wilson

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Dennis W. Wolan

object named as

Dennis W Wolan

2

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author name string

Cheom-Gil Cheong

1

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Samantha E Greasley

3

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Patricia A Horton

4

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G Peter Beardsley

5

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language of work or name

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publication date

23 April 2004

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Journal of Biological Chemistry

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279

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17

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18034-45

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Structure and functional relationships in human pur H

1 reference

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The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

1 reference

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Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

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Structural insights into the avian AICAR transformylase mechanism

1 reference

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Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site

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The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling

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Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase

1 reference

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Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations

1 reference

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Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid

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Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

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Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid

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Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor

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Processing of X-ray diffraction data collected in oscillation mode

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AMoRe: an automated package for molecular replacement

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

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The CCP4 suite: programs for protein crystallography

1 reference

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Solvent-accessible surfaces of proteins and nucleic acids

1 reference

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The Protein Data Bank

1 reference

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Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase

1 reference

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Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

1 reference

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Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

1 reference

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A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A

1 reference

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A new scaffold for binding haem in the cytochrome domain of the extracellular flavocytochrome cellobiose dehydrogenase

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Role of the flavin domain residues, His689 and Asn732, in the catalytic mechanism of cellobiose dehydrogenase from phanerochaete chrysosporium.

1 reference

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Two active site asparagines are essential for the reaction mechanism of the class III anaerobic ribonucleotide reductase from bacteriophage T4.

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Acyl glycerol hydrolases: inhibitors, interface and catalysis

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1 reference

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CRYStallize: a crystallographic symmetry display and handling subpackage in TOM/FRODO

1 reference

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inferred from DOI database lookup

10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase

1 reference

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based on heuristic

inferred from DOI database lookup

Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

1 reference

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based on heuristic

inferred from DOI database lookup

Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase

1 reference

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based on heuristic

inferred from DOI database lookup

Multisubstrate analogue based on 5,8,10-trideazafolate

1 reference

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based on heuristic

inferred from DOI database lookup

Direct transfer of one-carbon units in the transformylations of de novo purine biosynthesis

1 reference

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based on heuristic

inferred from DOI database lookup

Rapid automated molecular replacement by evolutionary search

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1074/JBC.M313691200

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