(Q24310212)

cellular response to sterol depletion

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

absorption

0 references

author name string

Jiang Wang

1

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Bei-Bei Chu

2

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Liang Ge

3

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Bo-Liang Li

4

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Yan Yan

5

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Bao-Liang Song

Journal of Lipid Research

6

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language of work or name

English

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publication date

August 2009

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published in

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volume

50

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page(s)

1653-62

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issue

8

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cites work

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1 reference

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Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

19 March 2017

1 reference

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

19 March 2017

1 reference

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19 March 2017

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Membrane topology of human insig-1, a protein regulator of lipid synthesis

19 March 2017

1 reference

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

19 March 2017

1 reference

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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724045

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724045

Protein sensors for membrane sterols

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724045

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724045

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

27 September 2017

1 reference

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Ezetimibe blocks internalization of the NPC1L1/cholesterol complex

27 September 2017

1 reference

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Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice.

27 September 2017

1 reference

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A translational view on the biliary lipid secretory network

27 September 2017

1 reference

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Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

27 September 2017

1 reference

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Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake

27 September 2017

1 reference

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Niemann-Pick type C disease and intracellular cholesterol trafficking

27 September 2017

1 reference

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Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

27 September 2017

1 reference

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Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

27 September 2017

1 reference

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The discovery of ezetimibe: a view from outside the receptor

27 September 2017

1 reference

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The sterol-sensing domain: multiple families, a unique role?

27 September 2017

1 reference

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Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

27 September 2017

1 reference

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Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.

27 September 2017

1 reference

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Cholesterol and coronary heart disease. Future directions

27 September 2017

1 reference

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Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

27 September 2017

1 reference

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Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724045

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.

30 May 2018

1 reference

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The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2724045

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1194%2FJLR.M800669-JLR200

Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1194%2FJLR.M800669-JLR200

Localization and role of NPC1L1 in cholesterol absorption in human intestine

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1194%2FJLR.M800669-JLR200

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19325169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19325169