(Q24313123)

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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262 (English)

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Alzheimer's disease

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based on heuristic

inferred from title

phosphorylation

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microtubule associated protein tau

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GOA release 2020-03-11

positive regulation of microtubule polymerization

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GOA release 2020-03-11

Eckhard Mandelkow

8

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Eva-Maria Mandelkow

7

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object named as

G Drewes

1

author given names

G

author last names

Drewes

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PubMed publication ID

9 December 2023

Eva-Maria Mandelkow

7

object named as

E M Mandelkow

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author name string

B Trinczek

2

author given names

B

author last names

Trinczek

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PubMed publication ID

9 December 2023

S Illenberger

3

author given names

S

author last names

Illenberger

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PubMed publication ID

9 December 2023

J Biernat

4

author given names

J

author last names

Biernat

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PubMed publication ID

9 December 2023

G Schmitt-Ulms

5

author given names

G

author last names

Schmitt-Ulms

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PubMed publication ID

9 December 2023

H E Meyer

6

author given names

H E

author last names

Meyer

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PubMed publication ID

9 December 2023

E Mandelkow

8

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language of work or name

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publication date

31 March 1995

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Journal of Biological Chemistry

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270

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13

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7679-88

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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Microheterogeneity of microtubule-associated tau proteins is due to differences in phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tau protein binds to microtubules through a flexible array of distributed weak sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

High sensitivity HPLC assay for GABA in brain dialysis studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Microtubule stabilization by assembly-promoting microtubule-associated proteins: a repeat performance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tau protein function in living cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Microtubule organization and dynamics dependent on microtubule-associated proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Peptides corresponding to the second repeated sequence in MAP-2 inhibit binding of microtubule-associated proteins to microtubules.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Fetal-type phosphorylation of the tau in paired helical filaments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Protein kinase recognition sequence motifs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

The carboxyl third of tau is tightly bound to paired helical filaments.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Structural stability of paired helical filaments requires microtubule-binding domains of Tau: A model for self-association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Non-motor microtubule-associated proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

The disordered neuronal cytoskeleton in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

The microtubule binding domain of tau protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tau as a marker for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Tubulin domains probed by limited proteolysis and subunit-specific antibodies.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Use of T7 RNA polymerase to direct expression of cloned genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Dynamics of microtubules from erythrocyte marginal bands

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

2 references

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

21 January 2018

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination and location of phosphoserine in proteins and peptides by conversion to S-ethylcysteine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

Domains of tau protein and interactions with microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

Strategies for nonradioactive methods in the localization of phosphorylated amino acids in proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.13.7679

7 January 2021

based on heuristic

inferred from DOI database lookup

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