(Q24316408)

English

Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1

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scholarly article

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Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1 (English)

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congenital disorder

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Lymphoid enhancer binding factor 1

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GOA release 2020-03-11

positive regulation of transcription, DNA-templated

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GOA release 2020-03-11

severe congenital neutropenia

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based on heuristic

inferred from title

author name string

Julia Skokowa

1

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John Paul Fobiwe

2

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Lan Dan

3

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Basant Kumar Thakur

4

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Karl Welte

5

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language of work or name

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publication date

1 October 2009

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114

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14

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3044-51

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Proteolytic cleavage of granulocyte colony‐stimulating factor and its receptor by neutrophil elastase induces growth inhibition and decreased cell surface expression of the granulocyte colony‐stimulating factor receptor

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Degradation of BM SDF-1 by MMP-9: the role in G-CSF-induced hematopoietic stem/progenitor cell mobilization

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

C/EBPbeta is required for 'emergency' granulopoiesis.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcription factors in myeloid development: balancing differentiation with transformation.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

C/EBPalpha and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional control of granulocyte and monocyte development

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Severe congenital neutropenia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Severe congenital neutropenia: inheritance and pathophysiology

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Neutrophil elastase in cyclic and severe congenital neutropenia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

Dysregulation of transcriptions in primary granule constituents during myeloid proliferation and differentiation in patients with severe congenital neutropenia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2008-11-188755

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1182/BLOOD-2008-11-188755

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