(Q24316869)

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Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2

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Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2 (English)

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Toshihisa Ishikawa

6

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Toshihisa Ishikawa

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Yu Toyoda

4

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ORCID Public Data File 2021

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Hiroshi Nakagawa

1

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Kanako Wakabayashi-Nakao

2

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Ai Tamura

3

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Shoko Koshiba

5

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publication date

December 2009

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276

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24

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7237-52

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A multidrug resistance transporter from human MCF-7 breast cancer cells

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Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells

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BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia

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Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)

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ABCG2: a perspective.

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High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells

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The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

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Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.

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The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins

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Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk

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The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

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Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk

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The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

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Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion

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Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.

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Pharmacogenomic importance of ABCG2.

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Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.

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Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2.

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Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations

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Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein

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N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane

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Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2).

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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

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Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter

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Setting the standards: quality control in the secretory pathway

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Roles of N-linked glycans in the endoplasmic reticulum

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Role of N-oligosaccharide endoplasmic reticulum processing reactions in glycoprotein folding and degradation

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Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2.

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ER-associated degradation in protein quality control and cellular regulation

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Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

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High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.

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Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec® ) across the mouse blood-brain barrier

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Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells

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Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse

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Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.

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Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperones

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ABCG2: structure, function and role in drug response

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