(Q24319540)

English

Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner

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scholarly article

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Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner (English)

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2'-5' oligoadenylate synthetase 1A

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GOA release 2020-03-11

Hepatitis C virus

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based on heuristic

inferred from title

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author name string

Takashi Taguchi

1

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Motoko Nagano-Fujii

2

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Masato Akutsu

3

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Hiroyasu Kadoya

4

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Shinji Ohgimoto

5

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Satoshi Ishido

6

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Hak Hotta

7

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language of work or name

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publication date

April 2004

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Journal of General Virology

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85

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Pt 4

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959-69

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Effect of interferon treatment on serum 2',5'-oligoadenylate synthetase levels in hepatitis C-infected patients

1 reference

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7 January 2021

based on heuristic

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Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: a prospective study

1 reference

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7 January 2021

based on heuristic

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Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication

1 reference

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7 January 2021

based on heuristic

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Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

1 reference

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7 January 2021

based on heuristic

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Cell growth regulatory and antiviral effects of the P69 isozyme of 2-5 (A) synthetase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis

1 reference

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7 January 2021

based on heuristic

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Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization. International Committee on Virus Taxonomy

1 reference

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7 January 2021

based on heuristic

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

1 reference

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7 January 2021

based on heuristic

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Nuclear localization and intramolecular cleavage of N-terminally deleted NS5A protein of hepatitis C virus

1 reference

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7 January 2021

based on heuristic

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Evidence for a deficiency of interferon response in mononuclear cells from hepatitis C viremic patients

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus infection

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of specific mutations in active site motifs of 2',5'-oligoadenylate synthetase on enzymatic activity

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. The International HCV Collaborative Study Group

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient initiation of HCV RNA replication in cell culture

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Correlation between mutations in the interferon sensitivity-determining region of NS5A protein and viral load of hepatitis C virus subtypes 1b, 1c, and 2a

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1b strains obtained from patients with and without hepatocellular carcinoma

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of Hepatitis C Virus (HCV) Subtype 1b Strains That Are Highly, or Only Weakly, Associated with Hepatocellular Carcinoma on the Basis of the Secondary Structure of an Amino-Terminal Portion of the HCV NS3 Protein

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the interferon-inducible 2'-5'-oligoadenylate synthetase gene by hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of alpha interferon on the hepatitis C virus replicon

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

1 reference

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7 January 2021

based on heuristic

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Characterization of insulin-dependent diabetes mellitus induced by a new variant (DK-27) of encephalomyocarditis virus in DBA/2 mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Factors influencing the response to interferon therapy in chronic hepatitis C. Studies on viral genotype and induction of 2',5'-oligoadenylate synthetase in the liver and peripheral blood cells

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19513-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus type 1b (II) infection in France and Italy. Collaborative Study Group

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1099/VIR.0.19513-0

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