(Q24336040)

GOA release 2020-03-11

heparanase activity

1 reference

GOA release 2020-03-11

author

Israel Vlodavsky

10

0 references

Flonia Levy-Adam

1

0 references

Neta Ilan

8

0 references

Sari Feld

2

object named as

Sari Feld

0 references

author name string

Flonia Levy-Adam

1

0 references

Victoria Cohen-Kaplan

3

0 references

Anna Shteingauz

4

0 references

Miriam Gross

5

0 references

Gil Arvatz

6

0 references

Inna Naroditsky

7

0 references

Ilana Doweck

Journal of Biological Chemistry

9

0 references

language of work or name

English

0 references

publication date

3 September 2010

0 references

published in

0 references

volume

285

0 references

issue

36

0 references

page(s)

28010-9

0 references

cites work

Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Processing and activation of latent heparanase occurs in lysosomes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heterodimer formation is essential for heparanase enzymatic activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Human heparanase. Purification, characterization, cloning, and expression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

The impact of heparanese and heparin on cancer metastasis and angiogenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Cloning and functional expression of a human heparanase gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Human heparanase is localized within lysosomes in a stable form

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Polycomb silencers control cell fate, development and cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase: busy at the cell surface

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Low and high affinity receptors mediate cellular uptake of heparanase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Mammalian heparanase: what is the message?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase: a target for drug discovery in cancer and inflammation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

The role of syndecans in disease and wound healing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Cellular uptake of mammalian heparanase precursor involves low density lipoprotein receptor-related proteins, mannose 6-phosphate receptors, and heparan sulfate proteoglycans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase processing by lysosomal/endosomal protein preparation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Eosinophil major basic protein: first identified natural heparanase-inhibiting protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparanase affects adhesive and tumorigenic potential of human glioma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Secretion of Heparanase Protein Is Regulated by Glycosylation in Human Tumor Cell Lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Mechanism of activation of human heparanase investigated by protein engineering.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934666

Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116384

Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116384

Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116384

Undersulfated and glycol-split heparins endowed with antiangiogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116384

Heparanase-2 expression in normal ovarian epithelium and in benign and malignant ovarian tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116384

Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116384

Heparanase up-regulation in tongue cancer: tissue and saliva analysis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20576607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20576607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20576607