(Q24337784)

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Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro

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Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro (English)

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apoptotic process

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phosphorylation

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Baculoviral IAP repeat containing 5

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GOA release 2020-03-11

protein phosphorylation

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GOA release 2020-03-11

author name string

Rachel M A Barrett

1

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Rita Colnaghi

2

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Sally P Wheatley

3

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language of work or name

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publication date

1 February 2011

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10

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3

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538-48

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Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

IAPs: more than just inhibitors of apoptosis proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

HBXIP functions as a cofactor of survivin in apoptosis suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Survivin's dual role: an export's view

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Separating the anti-apoptotic and mitotic roles of survivin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

A p34(cdc2) survival checkpoint in cancer

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

https://api.crossref.org/works/10.4161/CC.10.3.14758

22 April 2017

Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

The anti-apoptosis protein, survivin, mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34(cdc2) cyclin-dependent kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

19 March 2017

Structural basis for phosphoserine-proline recognition by group IV WW domains

1 reference

https://api.crossref.org/works/10.4161/CC.10.3.14758

22 April 2017

Chromosomal passengers: conducting cell division

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

7 April 2017

One-thousand-and-one substrates of protein kinase CK2?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

7 April 2017

Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Liaisons between survivin and Plk1 during cell division and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Survivin as a global target of intrinsic tumor suppression networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

CK2 inhibits apoptosis and changes its cellular localization following ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

An IAP-IAP complex inhibits apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

A single amino acid change (Asp 53 --> Ala53) converts Survivin from anti-apoptotic to pro-apoptotic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Specific localization of the catalytic subunits of protein kinase CK2 at the centrosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Joining the cell survival squad: an emerging role for protein kinase CK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Protein p21(WAF1/CIP1) is phosphorylated by protein kinase CK2 in vitro and interacts with the amino terminal end of the CK2 beta subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Casein kinase II catalyzes a mitotic phosphorylation on threonine 1342 of human DNA topoisomerase IIalpha, which is recognized by the 3F3/2 phosphoepitope antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Immunocytochemical localization of casein kinase II during interphase and mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Casein kinase II is a predominantly nuclear enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

27 September 2017

A role for protein kinase CK2 in cell proliferation: evidence using a kinase-inactive mutant of CK2 catalytic subunit alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

30 May 2018

Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115020

30 May 2018

Survivin, cancer networks and pathway-directed drug discovery.

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Perturbation of survivin expression affects chromosome alignment and spindle checkpoint in mouse oocyte meiotic maturation

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2.

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis.

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast.

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Nuclear survivin has reduced stability and is not cytoprotective

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.3.14758

21 January 2018

Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/21252625

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469

1 reference

https://pubmed.ncbi.nlm.nih.gov/21252625

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/CC.10.3.14758

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