(Q55046676)

16 June 2018

review article

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title

Survivin, cancer networks and pathway-directed drug discovery. (English)

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16 June 2018

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1

Dario C Altieri

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16 June 2018

language of work or name

English

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publication date

1 January 2008

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16 June 2018

published in

Nature Reviews Cancer

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16 June 2018

volume

8

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16 June 2018

page(s)

61-70

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16 June 2018

issue

1

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16 June 2018

https://scigraph.springernature.com/pub.10.1038/nrc2293

exact match

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cites work

Cancer genes and the pathways they control

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Targeted cancer therapy

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EGF-ERBB signalling: towards the systems level

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Heat shock protein 90 as a molecular target for cancer therapeutics

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The case for survivin as a regulator of microtubule dynamics and cell-death decisions

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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The case for Survivin as mitotic regulator

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Survivin, a cancer target with an emerging role in normal adult tissues

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Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential

31 March 2020

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Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

31 March 2020

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Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters

31 March 2020

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Structural basis for phosphoserine-proline recognition by group IV WW domains

31 March 2020

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Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

31 March 2020

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Chromosome alignment and segregation regulated by ubiquitination of survivin

31 March 2020

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Role of the Survivin gene in pathophysiology

31 March 2020

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Analysis of human transcriptomes.

31 March 2020

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A role for survivin in chemoresistance of endothelial cells mediated by VEGF

31 March 2020

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Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib.

31 March 2020

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A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

31 March 2020

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Urine detection of survivin and diagnosis of bladder cancer

31 March 2020

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Promoting apoptosis as a strategy for cancer drug discovery

31 March 2020

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Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

31 March 2020

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Molecular requirements for kinetochore-associated microtubule formation in mammalian cells

31 March 2020

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The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly

31 March 2020

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The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone

31 March 2020

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Deterin, a new inhibitor of apoptosis from Drosophila melanogaster

31 March 2020

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The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2.

31 March 2020

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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.

31 March 2020

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The Connectivity Map: a new tool for biomedical research

31 March 2020

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Chromosomal passengers and the (aurora) ABCs of mitosis

31 March 2020

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Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together

31 March 2020

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Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis

31 March 2020

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The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization

31 March 2020

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Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo

31 March 2020

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The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression

31 March 2020

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A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension

31 March 2020

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Activated checkpoint kinase 2 provides a survival signal for tumor cells

31 March 2020

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Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

31 March 2020

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Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

31 March 2020

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Survivin modulates microtubule dynamics and nucleation throughout the cell cycle

31 March 2020

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Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

31 March 2020

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A p34(cdc2) survival checkpoint in cancer

31 March 2020

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Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

31 March 2020

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Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential

31 March 2020

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Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression

31 March 2020

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Survivin and molecular pathogenesis of colorectal cancer.

31 March 2020

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Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells

31 March 2020

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Aberrant regulation of survivin by the RB/E2F family of proteins

31 March 2020

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Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines

31 March 2020

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Regulation of survivin expression by IGF-1/mTOR signaling

31 March 2020

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Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells

31 March 2020

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Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein.

31 March 2020

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Regulation of survivin function by Hsp90

31 March 2020

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HBXIP functions as a cofactor of survivin in apoptosis suppression

31 March 2020

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Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection

31 March 2020

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Survivin splice variants regulate the balance between proliferation and cell death

31 March 2020

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Solution structure of human survivin and its binding interface with Smac/Diablo

31 March 2020

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Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

31 March 2020

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Regulation of mitochondrial Smac/DIABLO-selective release by survivin

31 March 2020

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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin

31 March 2020

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Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.

31 March 2020

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Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3

31 March 2020

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Mitosis-independent survivin gene expression in vivo and regulation by p53.

31 March 2020

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Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

1 reference

Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer.

31 March 2020

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Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression

31 March 2020

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Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin

31 March 2020

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Rational design of shepherdin, a novel anticancer agent.

31 March 2020

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Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

31 March 2020

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Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.

31 March 2020

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Essential role for survivin in early brain development

31 March 2020

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Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure

31 March 2020

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Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells

31 March 2020

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Cancer-specific activation of the survivin promoter and its potential use in gene therapy

31 March 2020

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Targeted therapy by disabling crossroad signaling networks: the survivin paradigm

31 March 2020

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

31 March 2020

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Control of apoptosis and mitotic spindle checkpoint by survivin

31 March 2020

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Anti-apoptosis gene, survivin, and prognosis of neuroblastoma

31 March 2020

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Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis.

31 March 2020

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Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

31 March 2020

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Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions

31 March 2020

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Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy

31 March 2020

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Cancer gene therapy using a survivin mutant adenovirus

31 March 2020

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Activation of cancer-specific gene expression by the survivin promoter

31 March 2020

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

31 March 2020

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An IAP-IAP complex inhibits apoptosis

31 March 2020

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Autologous dendritic cell vaccines for non-small-cell lung cancer.

31 March 2020

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Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer

31 March 2020

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A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins.

31 March 2020

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Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers

31 March 2020

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Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin

31 March 2020

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Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients

31 March 2020

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The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2293

1 reference

16 June 2018

Dimensions Publication ID

0 references

1 reference

16 June 2018