(Q40115775)

17 September 2017

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. (English)

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17 September 2017

Andrei Goga

1

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17 September 2017

Dun Yang

2

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17 September 2017

Aaron D Tward

3

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17 September 2017

David O Morgan

4

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17 September 2017

J Michael Bishop

5

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17 September 2017

language of work or name

English

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publication date

24 June 2007

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17 September 2017

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17 September 2017

13

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17 September 2017

820-827

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17 September 2017

7

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https://scigraph.springernature.com/pub.10.1038/nm1606

17 September 2017

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cites work

Complex translocation disrupts c-myc regulation in a human plasma cell myeloma

1 reference

c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points

21 January 2018

1 reference

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

21 January 2018

1 reference

7 January 2021

Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

1 reference

7 January 2021

Cyclin-dependent kinases: engines, clocks, and microprocessors

1 reference

7 January 2021

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

7 January 2021

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

1 reference

7 January 2021

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

1 reference

7 January 2021

c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway

1 reference

7 January 2021

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1 reference

7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

7 January 2021

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

1 reference

7 January 2021

Isolation and analysis of a mammalian temperature-sensitive mutant defective in G2 functions

1 reference

7 January 2021

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

7 January 2021

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

1 reference

7 January 2021

A matter of life and death

1 reference

7 January 2021

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1 reference

7 January 2021

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1 reference

7 January 2021

Cancer gene therapy using a survivin mutant adenovirus

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7 January 2021

Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis.

1 reference

7 January 2021

Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

1 reference

7 January 2021

A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors.

1 reference

7 January 2021

Regulation of cyclin expression and cell cycle progression in breast epithelial cells by the helix-loop-helix protein Id1.

1 reference

7 January 2021

Differential complementation of Bcr-Abl point mutants with c-Myc

1 reference

7 January 2021

c-Myc is necessary for DNA damage-induced apoptosis in the G(2) phase of the cell cycle

1 reference

7 January 2021

A p34(cdc2) survival checkpoint in cancer

1 reference

7 January 2021

The case for survivin as a regulator of microtubule dynamics and cell-death decisions

1 reference

7 January 2021

Rational design of shepherdin, a novel anticancer agent.

1 reference

7 January 2021

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

1 reference

7 January 2021

Production of high-titer helper-free retroviruses by transient transfection

1 reference

7 January 2021

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

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7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

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7 January 2021

Cell division and cell survival in the absence of survivin

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1606

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Dimensions Publication ID

17 September 2017

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1 reference