(Q24530531)

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Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD (English)

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Scully Dmel_CG7113

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GOA release 2020-03-11

11

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author name string

Naeem Shafqat

1

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Hanns-Ulrich Marschall

2

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Charlotta Filling

3

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Erik Nordling

4

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Xiao-Qiu Wu

5

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Lars Björk

6

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Johan Thyberg

7

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Eva Mårtensson

8

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Samina Salim

9

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Hans Jörnvall

10

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language of work or name

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publication date

15 November 2003

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Biochemical Journal

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376

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Pt 1

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49-60

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2-Methyl-3-Hydroxybutyryl-CoA Dehydrogenase Deficiency Is Caused by Mutations in the HADH2 Gene

1 reference

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24 March 2017

Intrinsic alcohol dehydrogenase and hydroxysteroid dehydrogenase activities of human mitochondrial short-chain L-3-hydroxyacyl-CoA dehydrogenase

1 reference

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An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

1 reference

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24 March 2017

Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223751

24 March 2017

Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223751

24 March 2017

Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase

1 reference

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The gene for the Alzheimer-associated beta-amyloid-binding protein (ERAB) is differentially expressed in the testicular Leydig cells of the azoospermic by w/w(v) mouse

1 reference

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Oxidation of corticosteroids to steroidal carboxylic acids by an enzyme preparation from hamster liver

1 reference

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Purification and properties of an NADPH-dependent 21-oxo-20-hydroxysteroid reductase (17beta-aldol reductase) from sheep liver. Isolation of the 20beta-glycol product

1 reference

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Comparative anatomy of the aldo-keto reductase superfamily

1 reference

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Mechanisms of protein import into mitochondria

1 reference

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Short-chain dehydrogenases/reductases (SDR): the 2002 update

1 reference

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27 September 2017

Import of mitochondrial proteins

1 reference

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Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

1 reference

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Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones

1 reference

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27 September 2017

Forms and functions of human SDR enzymes

1 reference

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27 September 2017

17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223751

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scully, an essential gene of Drosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-beta peptide-binding protein

1 reference

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Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions

1 reference

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Homology modeling by the ICM method

1 reference

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Synthesis and metabolism of vertebrate-type steroids by tissues of insects: a critical evaluation

1 reference

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The stereochemistry of enzymic reduction of 21-dehydrocortisol to cortisol

1 reference

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Oxidation of steroids with the 20β-hydroxy-21-oxo side chain to 20β-hydroxy-21-oic acids by horse liver aldehyde dehydrogenases

1 reference

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Molecular endocrinology of hydroxysteroid dehydrogenases

1 reference

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Mutation of tyrosine-194 and lysine-198 in the catalytic site of pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase

1 reference

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Flexible protein-ligand docking by global energy optimization in internal coordinates.

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Influence of E. coli infection on turnover and metabolism of cholic acid in germ-free rats

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Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis

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Coenzyme specificity of human monomeric carbonyl reductase: contribution of Lys-15, Ala-37 and Arg-38.

1 reference

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Function of human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase in androgen metabolism.

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Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity.

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Expression of human and rat carbonyl reductase in E. coli. Comparison of the recombinant enzymes

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homology modeling with internal coordinate mechanics: deformation zone mapping and improvements of models via conformational search

1 reference

https://pubmed.ncbi.nlm.nih.gov/12917011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human type 10 17β-hydroxysteroid dehydrogenase: molecular modelling and substrate docking

1 reference

https://pubmed.ncbi.nlm.nih.gov/12917011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20030877

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