(Q35109227)

6 August 2017

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title

Mechanisms of protein import into mitochondria. (English)

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6 August 2017

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Kaye N Truscott

1

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author name string

Katrin Brandner

series ordinal

2

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PubMed ID

12699647

6 August 2017

Nikolaus Pfanner

series ordinal

3

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PubMed ID

12699647

6 August 2017

language of work or name

English

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publication date

1 April 2003

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6 August 2017

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6 August 2017

13

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6 August 2017

R326-37

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6 August 2017

8

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Common principles of protein translocation across membranes

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Protein import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Versatility of the mitochondrial protein import machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Protein unfolding by mitochondria. The Hsp70 import motor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Delivery of nascent polypeptides to the mitochondrial surface

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Opening the door to mitochondrial protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Sequential action of two hsp70 complexes during protein import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Import of mitochondrial carriers mediated by essential proteins of the intermembrane space

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Protein insertion into the mitochondrial inner membrane by a twin-pore translocase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Domain structure of mitochondrial and chloroplast targeting peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The preprotein translocation channel of the outer membrane of mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Recognition of preproteins by the isolated TOM complex of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Cytoplasmic chaperones in precursor targeting to mitochondria: the role of MSF and hsp 70.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Binding of mitochondrial precursor proteins to the cytoplasmic domains of the import receptors Tom70 and Tom20 is determined by cytoplasmic chaperones

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tom5 functionally links mitochondrial preprotein receptors to the general import pore.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

A yeast mitochondrial outer membrane protein essential for protein import and cell viability

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment].

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The mitochondrial receptor complex: the small subunit Mom8b/Isp6 supports association of receptors with the general insertion pore and transfer of preproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Multistep assembly of the protein import channel of the mitochondrial outer membrane.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The dimensions of the protein import channels in the outer and inner mitochondrial membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Biogenesis of Polytopic Membrane Proteins: Membrane Segments Assemble within Translocation Channels prior to Membrane Integration

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the 'acid chain' hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The mitochondrial receptor complex: Mom22 is essential for cell viability and directly interacts with preproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Characterization of the mitochondrial inner membrane translocase complex: the Tim23p hydrophobic domain interacts with Tim17p but not with other Tim23p molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tim23 links the inner and outer mitochondrial membranes.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Functional and physical interactions of components of the yeast mitochondrial inner-membrane import machinery (MIM)

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The Mitochondrial Presequence Translocase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mitochondrial processing peptidases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

A mitochondrial protease with two catalytic subunits of nonoverlapping specificities.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Isolation and identification of a novel mitochondrial metalloprotease (PreP) that degrades targeting presequences in plants

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Protein unfolding by the mitochondrial membrane potential

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mitochondrial Hsp70/MIM44 complex facilitates protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The Hsp70 peptide-binding domain determines the interaction of the ATPase domain with Tim44 in mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Can Hsp70 proteins act as force-generating motors?

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Active unfolding of precursor proteins during mitochondrial protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Unfolding of preproteins upon import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The protein import motor of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Powering mitochondrial protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mitochondria Unfold Precursor Proteins by Unraveling Them From Their N-termini

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tim9, a new component of the TIM22.54 translocase in mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Human deafness dystonia syndrome is a mitochondrial disease

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Different import pathways through the mitochondrial intermembrane space for inner membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The role of the TIM8-13 complex in the import of Tim23 into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

A novel X-linked gene, DDP, shows mutations in families with deafness (DFN-1), dystonia, mental deficiency and blindness

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

OXA1, a Saccharomyces cerevisiae nuclear gene whose sequence is conserved from prokaryotes to eukaryotes controls cytochrome oxidase biogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

PET1402, a nuclear gene required for proteolytic processing of cytochrome oxidase subunit 2 in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

A mutation in cytochrome oxidase subunit 2 restores respiration of the mutant pet ts1402

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Insertion of proteins into the inner membrane of mitochondria: the role of the Oxa1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

YidC mediates membrane protein insertion in bacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Insertion into the mitochondrial inner membrane of a polytopic protein, the nuclear-encoded Oxa1p

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Oxa1p, which is required for cytochrome c oxidase and ATP synthase complex formation, is embedded in the mitochondrial inner membrane.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The Oxa1 Protein Forms a Homooligomeric Complex and Is an Essential Part of the Mitochondrial Export Translocase inNeurospora crassa

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Membrane translocation of mitochondrially coded Cox2p: distinct requirements for export of N and C termini and dependence on the conserved protein Oxa1p

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Oxa1p, an essential component of the N-tail protein export machinery in mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

N-terminal tail export from the mitochondrial matrix. Adherence to the prokaryotic "positive-inside" rule of membrane protein topology

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Peripheral mitochondrial inner membrane protein, Mss2p, required for export of the mitochondrially coded Cox2p C tail in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

The sorting signal of cytochrome b2 promotes early divergence from the general mitochondrial import pathway and restricts the unfoldase activity of matrix Hsp70.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2803%2900239-2

7 January 2021

10.1016/S0960-9822(03)00239-2

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12699647