(Q24537455)

5 July 2017

title

Breaking the Meyer-Overton rule: predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anesthetics (English)

1 reference

5 July 2017

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Cantor RS

1

1 reference

5 July 2017

language of work or name

English

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publication date

1 May 2001

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5 July 2017

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5 July 2017

volume

80

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5 July 2017

issue

5

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5 July 2017

page(s)

2284-2297

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General anaesthetic actions on ligand-gated ion channels

5 July 2017

cites work

1 reference

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24 March 2017

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Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

27 September 2017

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The influence of membrane lateral pressures on simple geometric models of protein conformational equilibria

27 September 2017

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Solute modulation of conformational equilibria in intrinsic membrane proteins: apparent "cooperativity" without binding

27 September 2017

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Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart

27 September 2017

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Lipid composition and the lateral pressure profile in bilayers

27 September 2017

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Spring constants for channel-induced lipid bilayer deformations. Estimates using gramicidin channels

27 September 2017

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Lipid polymorphism and biomembrane function

27 September 2017

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Energetics of inclusion-induced bilayer deformations

27 September 2017

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Solid phase microextraction as a tool to determine membrane/water partition coefficients and bioavailable concentrations in in vitro systems

27 September 2017

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Contrasting membrane localization and behavior of halogenated cyclobutanes that follow or violate the Meyer-Overton hypothesis of general anesthetic potency

27 September 2017

1 reference

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Different distribution of fluorinated anesthetics and nonanesthetics in model membrane: a 19F NMR study

27 September 2017

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Models of lipid-protein interactions in membranes

27 September 2017

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Is there a cutoff in anesthetic potency for the normal alkanes?

27 September 2017

1 reference

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Molecular distributions in interphases: statistical mechanical theory combined with molecular dynamics simulation of a model lipid bilayer

27 September 2017

1 reference

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Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis

27 September 2017

1 reference

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Anesthetics reduce the magnitude of the membrane dipole potential. Measurements in lipid vesicles using voltage-sensitive spin probes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Molecular and cellular mechanisms of general anaesthesia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Correlation of general anesthetic potency with solubility in membranes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Can the lipid theories of anesthesia account for the cutoff in anesthetic potency in homologous series of alcohols?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Physical principles of membrane organization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Molecular mechanisms of general anaesthesia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Linear Relationships between Lipophilic Character and Biological Activity of Drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

The nature of the site of general anesthesia.

27 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

27 September 2017

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia

7 January 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Structure of the inverted hexagonal (HII) phase, and non-lamellar phase transitions of lipids

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Phospholipid interactions in model membrane systems. II. Theory

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Where do general anaesthetics act?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Molecular interactions between inhaled anesthetics and proteins.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Small-scale lipid-membrane structure: simulation versus experiment

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Anesthetic potencies of n-alkanols: results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Physicochemical approaches to the mode of action of general anesthetics.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Mapping the polarity profiles of general anesthetic target sites using n-alkane-(alpha, omega)-diols

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Wild-type Escherichia coli cells regulate the membrane lipid composition in a "window" between gel and non-lamellar structures.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Interactions of anesthetics with the water-hexane interface. A molecular dynamics study.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Effect of n-alkane kinetics in rats on potency estimations and the Meyer-Overton hypothesis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

Molecular properties of the "ideal" inhaled anesthetic: studies of fluorinated methanes, ethanes, propanes, and butanes

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

A cutoff in potency exists in the perfluoroalkanes

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301419

The lateral pressure profile in membranes: a physical mechanism of general anesthesia

29 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Partition coefficients of alkanols in lipid bilayer/water

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Spatial and energetic-entropic decomposition of surface tension in lipid bilayers from molecular dynamics simulations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Self-consistent-field modeling of complex molecules with united atom detail in inhomogeneous systems. Cyclic and branched foreign molecules in dimyristoylphosphatidylcholine membranes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Zur Theorie der Alkoholnarkose

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Zur Theorie der Alkoholnarkose

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Nicotinic acetylcholine receptor at 9 A resolution.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Acetylcholine receptor channel imaged in the open state

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

Location of hexane in lipid bilayers determined by neutron diffraction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2801%2976200-5

10.1016/S0006-3495(01)76200-5

7 January 2021

Identifiers

DOI

1 reference

5 July 2017

1 reference

5 July 2017

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