(Q24595862)

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Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus

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scholarly article

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Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus (English)

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Streptomyces clavuligerus

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Streptomyces katsurahamanus

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Streptomyces griseus

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Streptomyces jumonjinensis

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clavulanic acid

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4-Oxa-1-azabicyclo[3.2.0]heptan-7-one

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object named as

Susan E Jensen

5

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Perrin H. Beatty

object named as

Perrin H Beatty

4

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author name string

Kapil Tahlan

1

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Hyeon Ung Park

2

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Annie Wong

3

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language of work or name

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publication date

March 2004

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full work available at URL

https://europepmc.org/articles/pmc353097?pdf=render

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1128/aac.48.3.930-939.2004?email=unpaywall_01@example.com

Antimicrobial Agents and Chemotherapy

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48

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3

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930-9

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online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1128/aac.48.3.930-939.2004?email=unpaywall_01@example.com

access restriction status

1 reference

based on heuristic

inferred from online access status

The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

beta-Lactam synthetase: a new biosynthetic enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

Biosynthesis and metabolism of arginine in bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

Chemistry and biosynthesis of clavulanic acid and other clavams

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

24 March 2017

Production of single-stranded plasmid DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

7 April 2017

Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Biosynthesis and molecular genetics of clavulanic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Cloning and endonuclease restriction analysis of argF and of the control region of the argECBH bipolar operon in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

27 September 2017

Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

30 May 2018

Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

30 May 2018

Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

30 May 2018

Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

30 May 2018

An improved aminoglycoside resistance gene cassette for use in gram-negative bacteria and Streptomyces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

30 May 2018

Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

30 May 2018

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

28 November 2018

Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

28 November 2018

Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=353097

28 November 2018

Naturally-occurring beta-lactamase inhibitors with antibacterial activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14982786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to penicillins by cell-free extracts of Streptomyces clavuligerus

1 reference

https://pubmed.ncbi.nlm.nih.gov/14982786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces

1 reference

https://pubmed.ncbi.nlm.nih.gov/14982786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origin of the β-Lactam Carbons in Clavulanic Acid from an Unusual Thiamine Pyrophosphate-Mediated Reaction

1 reference

https://api.crossref.org/works/10.1128%2FAAC.48.3.930-939.2004

7 January 2021

based on heuristic

inferred from DOI database lookup

The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway

1 reference

https://api.crossref.org/works/10.1128%2FAAC.48.3.930-939.2004

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

1 reference

https://api.crossref.org/works/10.1128%2FAAC.48.3.930-939.2004

7 January 2021

based on heuristic

inferred from DOI database lookup

Streptomyces clavuligerus sp. nov., a -Lactam Antibiotic Producer

1 reference

https://api.crossref.org/works/10.1128%2FAAC.48.3.930-939.2004

7 January 2021

based on heuristic

inferred from DOI database lookup

Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

1 reference

https://api.crossref.org/works/10.1128%2FAAC.48.3.930-939.2004

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1128/AAC.48.3.930-939.2004

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PubMed publication ID

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