(Q24598483)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

0 references

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

25

Kenneth C Anderson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

23

Paul G Richardson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

11

Tanyel Kiziltepe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

12

Hiroshi Ikeda

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1

Naoya Mimura

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

24

Nikhil C Munshi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Mariateresa Fulciniti

2

object named as

Mariateresa Fulciniti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

3

Gullu Gorgun

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

5

Diana Cirstea

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

8

Claire Fabre

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

10

Hiroto Ohguchi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

author name string

Yu-Tzu Tai

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Loredana Santo

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Jiro Minami

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Yutaka Kawano

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Maureen French

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Martina Blumenthal

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Victor Tam

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Nathalie L Kertesz

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Uriel M Malyankar

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Mark Hokenson

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Tuan Pham

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Qingping Zeng

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

John B Patterson

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

language of work or name

English

0 references

publication date

26 April 2012

1 reference

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30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

volume

119

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

page(s)

5772-5781

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

30 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3382937/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Regulation of hepatic lipogenesis by the transcription factor XBP1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

The mammalian unfolded protein response

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

PI3K/p110{delta} is a novel therapeutic target in multiple myeloma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Bone marrow microenvironment and the identification of new targets for myeloma therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

The endoplasmic reticulum stress response in immunity and autoimmunity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Improved survival in multiple myeloma and the impact of novel therapies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Targeting XBP-1 as a novel anti-cancer strategy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Identification of genes modulated in multiple myeloma using genetically identical twin samples

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3382937

MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo

28 November 2018

1 reference

PubMed

12 December 2020

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

The development of a model for the homing of multiple myeloma cells to human bone marrow

1 reference

PubMed

12 December 2020

10.1182/BLOOD-2011-07-366633

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22538852%20AND%20SRC:MED&resulttype=core&format=json