(Q24625985)

English

Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)

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scholarly article

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Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM) (English)

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P. Jeffrey Conn

9

object named as

P Jeffrey Conn

author given names

P Jeffrey

author last names

Conn

1 reference

PubMed publication ID

29 November 2023

Craig W. Lindsley

10

object named as

Craig W Lindsley

author given names

Craig W

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Lindsley

1 reference

PubMed publication ID

29 November 2023

1

object named as

Cody J Wenthur

author given names

Cody J

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Wenthur

1 reference

PubMed publication ID

29 November 2023

Ryan R. Morrison

2

object named as

Ryan Morrison

author given names

Ryan

author last names

Morrison

1 reference

PubMed publication ID

29 November 2023

Kyle A. Emmitte

8

object named as

Kyle A Emmitte

author given names

Kyle A

author last names

Emmitte

1 reference

PubMed publication ID

29 November 2023

Katrina Smith Korfmacher

4

object named as

Katrina A Smith

author given names

Katrina A

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Smith

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PubMed publication ID

29 November 2023

author name string

Andrew S Felts

3

author given names

Andrew S

author last names

Felts

1 reference

PubMed publication ID

29 November 2023

Julie L Engers

5

author given names

Julie L

author last names

Engers

1 reference

PubMed publication ID

29 November 2023

Frank W Byers

6

author given names

Frank W

author last names

Byers

1 reference

PubMed publication ID

29 November 2023

J Scott Daniels

7

author given names

J Scott

author last names

Daniels

1 reference

PubMed publication ID

29 November 2023

language of work or name

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publication date

27 June 2013

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Journal of Medicinal Chemistry

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56

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12

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5208-12

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Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

7 April 2017

Pharmacology and functions of metabotropic glutamate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

7 April 2017

Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

27 September 2017

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769689

28 November 2018

Identifiers

10.1021/JM400439T

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