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Lentiviral vector gene therapy: effective and safe?
scientific article
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instance of
scholarly article
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editorial
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title
Lentiviral vector gene therapy: effective and safe?
(English)
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main subject
drug discovery
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gene therapy
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author name string
Derek A Persons
series ordinal
1
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language of work or name
English
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publication date
May 2010
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published in
Molecular Therapy
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volume
18
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issue
5
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page(s)
861-2
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cites work
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
retrieved
7 April 2017
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
retrieved
7 April 2017
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
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7 April 2017
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
1 reference
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PubMed Central
reference URL
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27 September 2017
Ten years of gene therapy for primary immune deficiencies.
1 reference
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PubMed Central
reference URL
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27 September 2017
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
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27 September 2017
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
1 reference
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PubMed Central
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27 September 2017
Transcription factor binding sites are genetic determinants of retroviral integration in the human genome
1 reference
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PubMed Central
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27 September 2017
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
1 reference
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PubMed Central
reference URL
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27 September 2017
Physiological promoters reduce the genotoxic risk of integrating gene vectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
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27 September 2017
Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome
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PubMed Central
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27 September 2017
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
1 reference
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PubMed Central
reference URL
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27 September 2017
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
1 reference
stated in
PubMed Central
reference URL
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27 September 2017
Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
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27 September 2017
Assessing the risk of T-cell malignancies in mouse models of SCID-X1.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
retrieved
27 September 2017
Gene therapy. Beta-thalassemia treatment succeeds, with a caveat
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
retrieved
30 May 2018
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890097
retrieved
28 November 2018
Identifiers
DOI
10.1038/MT.2010.70
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3903769
OpenCitations bibliographic resource ID
3903769
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3903769
PMC publication ID
2890097
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3903769
PubMed publication ID
20436489
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3903769
ResearchGate publication ID
43535448
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