(Q24642621)

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Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?

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scholarly article

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Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway? (English)

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organic chemistry

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3

object named as

Daniel Romo

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author name string

Gil Ma

1

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Henry Nguyen

2

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language of work or name

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publication date

24 May 2007

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Organic Letters

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9

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11

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2143-6

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Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

Total synthesis of salinosporamide A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

Proteasome inhibition as a novel therapeutic target in human cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

A simple stereocontrolled synthesis of salinosporamide A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

The proteasome as a target for cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

27 September 2017

Cinnabaramides A−G: Analogues of Lactacystin and Salinosporamide from a Terrestrial Streptomycete

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

28 November 2018

Synthesis, structure, and reactivity of unexpectedly stable spiroepoxy-beta-lactones obtained by epoxidation of 4-alkylidene-2-oxetanones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

28 November 2018

Asymmetric synthesis of bicyclic beta-lactones via the intramolecular, nucleophile-catalyzed aldol lactonization: improved efficiency and expanded scope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

28 November 2018

Amine-catalyzed coupling of aldehydes and ketenes derived from Fischer carbene complexes: formation of beta-lactones and enol ethers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

28 November 2018

Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518687

28 November 2018

Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic, asymmetric preparation of ketene dimers from acid chlorides

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

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Proteasome inhibitor drugs on the rise

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

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Bicyclic- and tricyclic-beta-lactones via organonucleophile-promoted bis-cyclizations of keto acids: Enantioselective synthesis of (+)-dihydroplakevulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

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Novel bicyclization reaction leading to a fused beta-lactone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

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Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New synthetic route for the enantioselective total synthesis of salinosporamide A and biologically active analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramolecular, nucleophile-catalyzed aldol-lactonization (NCAL) reactions: catalytic, asymmetric synthesis of bicyclic beta-lactones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total synthesis and biological activity of lactacystin, omuralide and analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A concise total synthesis of salinosporamide A

1 reference

https://pubmed.ncbi.nlm.nih.gov/17477539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/OL070616U

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