(Q24645530)

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Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

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Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1 (English)

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Joseph Sodroski

18

object named as

Joseph Sodroski

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Pascal Poignard

2

object named as

Pascal Poignard

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Christos J Petropoulos

12

object named as

Christos J Petropoulos

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16

object named as

Peter D Kwong

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Dennis R. Burton

19

object named as

Dennis R Burton

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Richard T. Wyatt

17

object named as

Richard T Wyatt

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author name string

Aran F Labrijn

1

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Aarti Raja

3

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Michael B Zwick

4

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Karla Delgado

5

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Michael Franti

6

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James Binley

7

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Veronique Vivona

8

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Christoph Grundner

9

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Chih-Chin Huang

10

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Miro Venturi

11

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Terri Wrin

13

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Dimiter S Dimitrov

14

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James Robinson

15

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language of work or name

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publication date

October 2003

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Journal of Virology

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77

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10557-65

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19

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Energetics of the HIV gp120-CD4 binding reaction

1 reference

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

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Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

1 reference

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

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The CCP4 suite: programs for protein crystallography

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A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

2 references

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Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

1 reference

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Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

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Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

2 references

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7 April 2017

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Redox-Triggered Infection by Disulfide-Shackled Human Immunodeficiency Virus Type 1 Pseudovirions

1 reference

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Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes

1 reference

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Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin

1 reference

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Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies.

1 reference

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Antigenic properties of the human immunodeficiency virus envelope during cell-cell fusion

1 reference

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The antiviral activity of antibodies in vitro and in vivo.

1 reference

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Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 infection by altering the position of the gp120 V1/V2 variable loops

1 reference

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Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex

1 reference

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V2 loop glycosylation of the human immunodeficiency virus type 1 SF162 envelope facilitates interaction of this protein with CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4 binding site antibodies

1 reference

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Variable-loop-deleted variants of the human immunodeficiency virus type 1 envelope glycoprotein can be stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits

1 reference

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Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus

1 reference

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A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure

1 reference

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Sequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120.

1 reference

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Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1

1 reference

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Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication

1 reference

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Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein

1 reference

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27 September 2017

Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=228502

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Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies

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Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity

1 reference

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Conformational changes in cell surface HIV-1 envelope glycoproteins are triggered by cooperation between cell surface CD4 and co-receptors

1 reference

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Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein

1 reference

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Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization

1 reference

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CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

1 reference

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CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

1 reference

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Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120.

1 reference

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Genotypic and phenotypic characterization of HIV-1 patients with primary infection

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Differential regulation of cellular tropism and sensitivity to soluble CD4 neutralization by the envelope gp120 of human immunodeficiency virus type 1.

1 reference

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Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1.

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Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.

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Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding

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Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=228502

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Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=228502

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Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding

1 reference

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Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

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Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity.

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Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

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Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4

1 reference

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Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range

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1 reference

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Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=228502

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gp120: Biologic aspects of structural features

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=228502

28 November 2018

Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1).

1 reference

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Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120

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https://pubmed.ncbi.nlm.nih.gov/12970440

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Fusin--a place for HIV-1 and T4 cells to meet

1 reference

https://pubmed.ncbi.nlm.nih.gov/12970440

12 December 2020

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