(Q24648015)

2

0 references

A Menoyo

3

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E Del Rio

4

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M Gómez-Pardo

5

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M Baiget

British Journal of Cancer

6

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language of work or name

English

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publication date

16 August 2004

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published in

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volume

91

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issue

4

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page(s)

678-82

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cites work

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini

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A simple salting out procedure for extracting DNA from human nucleated cells

7 April 2017

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Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype

7 April 2017

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Irinotecan pathway genotype analysis to predict pharmacokinetics

7 April 2017

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Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

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Impact of body-size measures on irinotecan clearance: alternative dosing recommendations

22 April 2017

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Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

28 September 2017

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Irinotecan in the treatment of colorectal cancer: clinical overview

28 September 2017

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Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.

28 September 2017

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Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group

28 September 2017

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Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer.

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Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

28 September 2017

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Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

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Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation.

28 September 2017

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Preclinical antitumor activity and pharmacokinetics of irinotecan (CPT-11) in tumor-bearing mice

28 September 2017

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Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

30 May 2018

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UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

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Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

21 January 2018

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12 December 2020

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea

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12 December 2020

Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions

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12 December 2020

Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reports

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12 December 2020

Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions

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12 December 2020

UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan

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12 December 2020

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6602042

1 reference

Dimensions Publication ID

1001636776

0 references

1 reference

1 reference

PubMed publication ID

15280927

1 reference